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Polypharmacy and sarcopenia in hospitalized older patients: results of the GLISTEN study
Luca Agosta1, Mario Bo2, Lara Bianchi3
1Geriatria e Malattie Metaboliche dell'Osso, Dipartimento di Scienze Mediche, University of Torino, Turin, Italy. lucagosta@yahoo.it.
Background:
Recently the Berlin Aging Study II (BASE-II) showed that polypharmacy is associated with clinically relevant sarcopenia among community-dwelling older persons. Here we report findings from the GLISTEN study about the association of polypharmacy with sarcopenia among older medical in-patients.
Methods:
The GLISTEN study investigated prevalence and clinical correlates of sarcopenia in older patients admitted to geriatric and internal medicine acute care wards of 12 Italian hospitals.
Results:
In this sample of older medical in-patients with high prevalence of sarcopenia (34.7%) and polypharmacy (70.2%) we did not observe a significant association of polypharmacy with sarcopenia.
Conclusions:
Present findings demonstrate that the association of polypharmacy with sarcopenia, observed in the BASE-II study, is not evident in the GLISTEN sample, being our patients significantly older, more multi-morbid, with high prevalence of sarcopenia and polypharmacy, suggesting that this association might vary according to the heterogeneous health, functional, and nutritional characteristics of older people.
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