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Related Concept Videos

Protein Kinases and Phosphatases02:54

Protein Kinases and Phosphatases

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Proteins undergo chemical modifications that trigger changes in the charge, structure, and conformation of the proteins. Phosphorylation, acetylation, glycosylation, nitrosylation, ubiquitination, lipidation, methylation, and proteolysis are various protein modifications that regulate protein activity. Such modifications are usually enzyme-driven.
Protein kinases
Many proteins in the cell are regulated by phosphorylation, the addition of a phosphate group. A family of enzymes called kinases...
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Protein Kinases and Phosphatases02:54

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Aging01:26

Aging

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
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Receptor Tyrosine Kinases01:26

Receptor Tyrosine Kinases

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Receptor tyrosine kinases or RTKs are membrane-bound receptors that phosphorylate specific tyrosine on protein substrates. RTKs regulate cellular growth, differentiation, survival, and migration. They contain an extracellular ligand binding domain, a transmembrane domain, and a cytosolic tail with intrinsic kinase activity. Several extracellular signaling molecules activate RTKs in one or more ways and relay the signal downstream. Ligands such as platelet-derived growth factor (PDGF) or...
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The Effect of Aging on Tissues01:19

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

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The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
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Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay
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Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay

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Creatine, Creatine Kinase, and Aging.

Nathalie Sumien1, Ritu A Shetty1, Eric B Gonzales2

  • 1Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, USA.

Sub-Cellular Biochemistry
|February 20, 2019
PubMed
Summary
This summary is machine-generated.

Creatine supplementation may combat age-related functional decline by supporting cellular energy. This review explores creatine

Keywords:
AgingAnti-aging interventionCreatineCreatine kinaseMotor and cognitive functionMuscle functionSupplementation

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Area of Science:

  • Gerontology
  • Nutritional Biochemistry
  • Metabolic Science

Background:

  • Aging populations necessitate interventions for functional decline.
  • Dietary supplements, including creatine, are popular for health claims.
  • Creatine is vital for cellular energy via ATP replenishment.

Purpose of the Study:

  • To summarize creatine and creatine kinase function in normal physiology.
  • To examine how altered creatine system levels impact function.
  • To investigate creatine's effects on aging and potential reversal.

Main Methods:

  • Literature review of creatine and creatine kinase physiology.
  • Analysis of aging's impact on the creatine system.
  • Evaluation of creatine supplementation in aging.

Main Results:

  • Creatine plays a key role in cellular metabolism and ATP regeneration.
  • Dysregulation of the creatine system can lead to functional impairments.
  • Aging affects creatine system dynamics, potentially impacting cellular energy.

Conclusions:

  • Creatine supplementation may offer a strategy to mitigate age-related functional deficits.
  • Understanding the creatine system is crucial for addressing aging-related health issues.
  • Further research into creatine's role in reversing aging processes is warranted.