Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Aging01:26

Aging

673
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
673
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

3.5K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.5K
Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

3.5K
The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
3.5K
Physiology of Enteric Nervous System and Gut Health01:05

Physiology of Enteric Nervous System and Gut Health

938
The gastrointestinal tract, responsible for the digestion and absorption of nutrients, is safeguarded by the intestinal barrier, which consists of secretory, physical, and immune components. At the forefront is the secretory barrier, composed of essential elements such as mucus, gut microbiota, and defense proteins. They collaborate to break down food particles, facilitate nutrient absorption, and maintain optimal gut health. These secretory components ensure the smooth functioning of the...
938
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

202
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
202
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

692
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
692

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A multi-ingredient food supplement slows age-dependent decline of mobility and influences gene expression in C. elegans.

Biogerontology·2026
Same author

ADORA2B/ador-1 is required for multi-system transcriptional adaptation to mild hypoxia and healthspan extension in C. elegans.

Free radical biology & medicine·2026
Same author

The need to increase support for healthy ageing and longevity research in the EU by establishing a Coordination and Support Programme on Healthy Ageing and Longevity.

Mechanisms of ageing and development·2026
Same author

From human to superhuman: the impact of the microbiome on physiology.

The Journal of physiology·2025
Same author

New tools to monitor <i>Pseudomonas aeruginosa</i> infection and biofilms <i>in vivo</i> in <i>C. elegans</i>.

Frontiers in cellular and infection microbiology·2024
Same author

Folates, bacteria and ageing: insights from the model organism <i>C. elegans</i> in the study of nutrition and ageing.

The Proceedings of the Nutrition Society·2024

Related Experiment Video

Updated: Jan 29, 2026

A Method to Assess Bacteriocin Effects on the Gut Microbiota of Mice
07:54

A Method to Assess Bacteriocin Effects on the Gut Microbiota of Mice

Published on: July 25, 2017

14.7K

The Gut Microbiota and Ageing.

Claire Maynard1,2, David Weinkove3

  • 1Department of Biosciences, Durham University, Durham, UK.

Sub-Cellular Biochemistry
|February 20, 2019
PubMed
Summary
This summary is machine-generated.

The gut microbiota, or the collection of microbes in our digestive tract, significantly impacts aging. Studies in model organisms show that gut microbes can accelerate aging, but interventions may promote healthier aging in humans.

Keywords:
C. elegansDysbiosisFolateHuman gut microbiotaInflammationIntestinal permeability

More Related Videos

Applying Advanced In Vitro Culturing Technology to Study the Human Gut Microbiota
06:23

Applying Advanced In Vitro Culturing Technology to Study the Human Gut Microbiota

Published on: February 15, 2019

14.8K
Visualization of Microbiota in Tick Guts by Whole-mount In Situ Hybridization
08:30

Visualization of Microbiota in Tick Guts by Whole-mount In Situ Hybridization

Published on: June 1, 2018

10.0K

Related Experiment Videos

Last Updated: Jan 29, 2026

A Method to Assess Bacteriocin Effects on the Gut Microbiota of Mice
07:54

A Method to Assess Bacteriocin Effects on the Gut Microbiota of Mice

Published on: July 25, 2017

14.7K
Applying Advanced In Vitro Culturing Technology to Study the Human Gut Microbiota
06:23

Applying Advanced In Vitro Culturing Technology to Study the Human Gut Microbiota

Published on: February 15, 2019

14.8K
Visualization of Microbiota in Tick Guts by Whole-mount In Situ Hybridization
08:30

Visualization of Microbiota in Tick Guts by Whole-mount In Situ Hybridization

Published on: June 1, 2018

10.0K

Area of Science:

  • Microbiology
  • Geroscience
  • Immunology

Background:

  • The human gut microbiota's role in aging is complex and varies individually.
  • Differences in gut microbe composition exist between elderly and younger populations.
  • It remains unclear if these microbial differences drive aging or are merely a consequence of it.

Purpose of the Study:

  • To investigate the causal role of the gut microbiota in the aging process.
  • To determine if gut microbes can accelerate or decelerate host aging.
  • To explore potential microbial interventions for promoting healthy aging.

Main Methods:

  • Longitudinal studies in Drosophila melanogaster (fruit flies).
  • Lifespan analysis and antibiotic treatments in killifish.
  • Germ-free mouse models with microbial transplantation.
  • Studies in Caenorhabditis elegans (nematodes) with specific bacterial strains.

Main Results:

  • Microbial composition changes precede host aging in fruit flies; antibiotics extend lifespan.
  • Younger killifish gut microbes extend lifespan in older killifish.
  • Old mouse gut microbes induce inflammation in germ-free mice, unlike young mouse microbes.
  • Specific bacterial metabolic interventions, like inhibiting folate synthesis, extend lifespan in C. elegans.

Conclusions:

  • Gut microbes, particularly Proteobacteria, can drive aging through inflammation and intestinal degradation.
  • Microbes can become more detrimental with age.
  • Manipulating the gut microbiota holds promise for interventions to maintain health in old age.