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Nutrition and Ageing.
Fiona C Malcomson1, John C Mathers2
1Human Nutrition Research Centre, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.
Sub-Cellular Biochemistry
|February 20, 2019
Summary
Healthy lifestyle choices, like plant-based diets, can slow the ageing process. Nutrition and exercise impact all nine hallmarks of ageing by reducing damage and enhancing repair, promoting healthier aging.
Area of Science:
- Gerontology
- Nutritional Science
- Molecular Biology
Background:
- Ageing is a modifiable process influenced by lifestyle factors such as diet and physical activity.
- Plant-based diets are linked to healthier ageing and reduced risk of age-related diseases.
- Obesity accelerates ageing and increases the risk of chronic diseases like cardiovascular disease (CVD) and type 2 diabetes (T2D).
Purpose of the Study:
- To explore the molecular mechanisms by which dietary factors influence ageing.
- To understand how lifestyle interventions can promote healthy ageing and independence.
- To identify cost-effective strategies for mitigating age-related frailty and multi-morbidity.
Main Methods:
- Review of evidence from human studies, cell systems, and animal models.
- Analysis of molecular pathways implicated in ageing.
- Societal and public health perspective on lifestyle interventions.
Main Results:
- Dietary choices likely influence all nine hallmarks of ageing.
- Better eating patterns may retard ageing by reducing inflammation, oxidative stress, and metabolic stress.
- Dietary interventions can enhance cellular repair mechanisms, contributing to healthier ageing.
Conclusions:
- Lifestyle interventions, particularly dietary changes, are crucial for promoting healthy ageing.
- Understanding molecular mechanisms can guide the development of effective anti-ageing strategies.
- There is an urgent societal need for accessible interventions to support active and independent ageing.
Keywords:
Dietary energy restrictionDietary patternsHallmarks of ageingMediterranean dietPlant-based dietsMore Related Videos
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