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A study on PLGA sustained release icariin/titanium dioxide nanotube composite coating.

F-F Wang¹, Y Li, H-C Liu

¹Medical College of Nankai University, Tianjin, P.R. China. liuff301@163.com.

European Review for Medical and Pharmacological Sciences

|February 20, 2019

Summary

Poly (lactic-co-glycolic acid) (PLGA) enhances icariin loading and sustained release on TiO2 nanotubes for improved osseointegration. The overlay method shows superior sustained release, while mixing offers better initial loading.

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Area of Science:

Biomaterials Science
Nanotechnology
Drug Delivery Systems

Background:

Icariin, a Chinese medicine compound, exhibits osteoinductive and osteogenic properties beneficial for enhancing implant osseointegration.
TiO2 nanotubes provide a platform for loading icariin, but their sustained release capacity is limited due to icariin's short half-life.
Achieving long-term stable drug release is crucial for maximizing the therapeutic benefits of implant coatings.

Purpose of the Study:

To enhance the sustained release of icariin from TiO2 nanotube composite coatings using poly (lactic-co-glycolic acid) (PLGA).
To investigate the effects of two PLGA loading methods (overlay and mixing) on the loading capacity and early release profile of the composite coating.
To evaluate the synergistic effects of PLGA and TiO2 nanotubes on improving osseointegration.

Main Methods:

Fabrication of icariin/TiO2 nanotube composite coatings.
Loading of PLGA onto the composite coatings using overlay and mixing methods.
Characterization using scanning electron microscopy and assessment of drug release kinetics.

Main Results:

PLGA significantly improved both the loading efficiency and sustained release of icariin compared to TiO2 nanotubes alone.
The overlay method extended drug release to 12 days, while the mixing method extended it to 10 days, compared to 9 days for TiO2 nanotubes.
Sustained release was primarily observed during the initial rapid release phase.

Conclusions:

PLGA incorporation effectively enhances the loading and sustained release properties of icariin/TiO2 nanotube composite coatings.
The overlay method demonstrates a superior sustained release effect for icariin.
The mixing method exhibits better initial drug loading performance.