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Updated: Jan 29, 2026

The Lambda Select cII Mutation Detection System
Published on: April 26, 2018
Mutation status and surgical selection
Georgios A Margonis1, Martin E Kreis2, Christopher L Wolfgang1
1Department of Surgery, Johns Hopkins University, School of Medicine, Baltimore, Maryland.
Abstract:
Current evidence cannot support denying metastasectomy in otherwise resectable patients solely based on their overall KRAS or BRAF mutational status. The combination of KRAS or BRAF mutational status with certain clinicopathologic characteristics has defined groups of patients who may not derive benefit from metastasectomy, but external validation is needed. The effect of certain KRAS or BRAF variants on survival may be more pronounced and therefore future studies should consider them for surgical selection.
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