Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Properties of Enantiomers and Optical Activity02:24

Properties of Enantiomers and Optical Activity

21.6K
It is essential to understand the difference between chiral and achiral interactions and the implications thereof in optical activity and their applications. Just as our feet, which are chiral, interact uniquely with chiral objects, such as a pair of shoes, but identically with achiral socks, enantiomers of a molecule exhibit different properties only when they interact with other chiral media. An example of a significant implication from this facet is the phenomenon known as optical activity,...
21.6K
Structural Properties and Dimensions of Lumber01:21

Structural Properties and Dimensions of Lumber

397
Wood's structural properties derive from fibers aligned along the tree's length, contributing significantly to its mechanical strength. Wood exhibits up to twenty times greater tensile strength along these fibers compared to across them, and generally shows better performance under compression than tension. The length of fibers varies, with hardwoods having fibers around one twenty-fifth inch long and softwoods ranging from one-eighth to one-third inch.
The strength characteristics of...
397
Structure and Physical Properties of Alkynes02:37

Structure and Physical Properties of Alkynes

13.2K
Introduction:
In nature, compounds containing both carbon and hydrogen are known as "hydrocarbons". Aliphatic hydrocarbons are compounds whose molecules contain saturated single bonds (i.e., alkanes) or unsaturated double or triple bonds. Alkenes contain carbon–carbon double bonds and have a structural formula CnH2n. Unsaturated hydrocarbons containing carbon–carbon triple bonds are called "alkynes" and are structurally represented by the formula CnH2n-2.
The...
13.2K
Local Anesthetics: Chemistry and Structure-Activity Relationship01:30

Local Anesthetics: Chemistry and Structure-Activity Relationship

6.6K
Local anesthetics (LAs) are drugs that induce a temporary loss of sensation in a limited body area, preventing pain. Cocaine was the first local anesthetic discovered in the late 19th century. Cocaine is a benzoic acid ester obtained from the leaves of coca shrubs and was often used for its psychotropic effects. Cocaine was first isolated in 1860 by Albert Niemann. Sigmund Freud studied the physiological actions of cocaine. Carl Koller later introduced it into clinical practice in 1884 as a...
6.6K
Physical and Chemical Properties of Matter02:57

Physical and Chemical Properties of Matter

166.1K
The characteristics that enable us to distinguish one substance from another are called properties.
166.1K
Structural Isomerism02:34

Structural Isomerism

21.7K
Isomerism in Complexes
Isomers are different chemical species that have the same chemical formula. Structural isomerism of coordination compounds can be divided into two subcategories, the linkage isomers and coordination-sphere isomers.
Linkage isomers occur when the coordination compound contains a ligand that can bind to the transition metal center through two different atoms. For example, the CN− ligand can bind through the carbon atom or through the nitrogen atom. Similarly, SCN− can...
21.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Publisher Correction: Scattering of Sculpted Light in Intact Brain Tissue, with implications for Optogenetics.

Scientific reports·2025
Same author

Shining Light in Mechanobiology: Optical Tweezers, Scissors, and Beyond.

ACS photonics·2024
Same author

Tired and stressed: direct holographic quasi-static stretching of aging echinocytes and discocytes in plasma using optical tweezers [Invited].

Biomedical optics express·2024
Same author

Far-Field Subwavelength Straight-Line Projection/Imaging by Means of a Novel Double-Near-Zero Index-Based Two-Layer Metamaterial.

Materials (Basel, Switzerland)·2021
Same author

Enhanced Signal-to-Noise and Fast Calibration of Optical Tweezers Using Single Trapping Events.

Micromachines·2021
Same author

Strong Transient Flows Generated by Thermoplasmonic Bubble Nucleation.

ACS nano·2020

Related Experiment Video

Updated: Jan 29, 2026

Using Optical Tweezers for the Generation of Hybrid Spheroids
12:11

Using Optical Tweezers for the Generation of Hybrid Spheroids

Published on: May 30, 2025

984

Measuring local properties inside a cell-mimicking structure using rotating optical tweezers.

Shu Zhang1, Lachlan J Gibson1, Alexander B Stilgoe1

  • 1Department of Physics, School of Mathematics and Physics, The University of Queensland, Brisbane, Queensland, Australia.

Journal of Biophotonics
|February 20, 2019
PubMed
Summary

Understanding cellular mechanics requires studying intracellular material rheology. This research uses optical tweezers and liposomes to model cell interiors, revealing how membranes affect probe particle movement for advanced micro/nanorheology.

Keywords:
angular momentumhydrodynamicsliposomesmiro/nanorheologyoptical tweezerswall effects

More Related Videos

Direct Force Measurements of Subcellular Mechanics in Confinement using Optical Tweezers
09:56

Direct Force Measurements of Subcellular Mechanics in Confinement using Optical Tweezers

Published on: August 31, 2021

5.5K
Quantitative Analysis of Viscoelastic Properties of Red Blood Cells Using Optical Tweezers and Defocusing Microscopy
08:03

Quantitative Analysis of Viscoelastic Properties of Red Blood Cells Using Optical Tweezers and Defocusing Microscopy

Published on: March 25, 2022

1.8K

Related Experiment Videos

Last Updated: Jan 29, 2026

Using Optical Tweezers for the Generation of Hybrid Spheroids
12:11

Using Optical Tweezers for the Generation of Hybrid Spheroids

Published on: May 30, 2025

984
Direct Force Measurements of Subcellular Mechanics in Confinement using Optical Tweezers
09:56

Direct Force Measurements of Subcellular Mechanics in Confinement using Optical Tweezers

Published on: August 31, 2021

5.5K
Quantitative Analysis of Viscoelastic Properties of Red Blood Cells Using Optical Tweezers and Defocusing Microscopy
08:03

Quantitative Analysis of Viscoelastic Properties of Red Blood Cells Using Optical Tweezers and Defocusing Microscopy

Published on: March 25, 2022

1.8K

Area of Science:

  • Biophysics
  • Cellular Mechanics
  • Nanotechnology

Background:

  • Investigating intracellular material rheology is crucial for understanding cellular and subcellular processes.
  • Optical traps are valuable tools for manipulating micro/nano objects in biological fluid studies.
  • Challenges exist in understanding probe particle mobility near cellular membranes and organelles.

Purpose of the Study:

  • To investigate the rheological properties of intracellular materials using a biomimetic model.
  • To theoretically and experimentally study the mechanical properties within a liposome using optical tweezers.
  • To predict hydrodynamic interactions between membranes and internal probe particles at submicron distances.

Main Methods:

  • Utilized liposomes (unilamellar lipid vesicles) as a biomimetic model for living cells.
  • Employed optical tweezers to trap and rotate a probe particle within the liposome.
  • Combined theoretical and experimental approaches to analyze rheological properties.

Main Results:

  • Demonstrated the system's capability to predict hydrodynamic interactions between 3D membranes and internal probe particles.
  • Quantified the influence of membrane proximity on probe particle mobility within submicron distances.
  • Established a method for studying rheology in confined cellular environments.

Conclusions:

  • The developed system accurately models hydrodynamic interactions in confined cellular environments.
  • This approach has potential for designing high-resolution optical micro/nanorheology techniques for in vivo applications.
  • Understanding these interactions is key to advancing studies of cellular mechanics and dynamics.