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A Comprehensive Framework for Physiologically-Based Pharmacokinetic Modeling in Matlab.
Felix Stader1,2,3, Melissa A Penny2,3, Marco Siccardi4
1Division of Infectious Diseases and Hospital Epidemiology, Departments of Medicine and Clinical Research, University Hospital Basel, Basel, Switzerland.
CPT: Pharmacometrics & Systems Pharmacology
|February 20, 2019
Summary
Physiologically-based pharmacokinetic (PBPK) models aid drug development for special populations. This tutorial simplifies building PBPK models in Matlab for drug disposition and interaction predictions.
Area of Science:
- Pharmacology
- Computational Biology
- Drug Development
Background:
- Physiologically-based pharmacokinetic (PBPK) models are crucial for predicting drug behavior in diverse populations.
- Clinical trials in special populations (e.g., children, elderly) present significant logistical and ethical challenges.
- Developing and coding PBPK models can be complex and time-consuming.
Purpose of the Study:
- To provide a practical tutorial for constructing a whole-body PBPK model.
- To demonstrate the application of PBPK models in Matlab for pharmacological research.
- To address challenges in coding PBPK models for specific research questions.
Main Methods:
- Development of a whole-body PBPK model using Matlab.
- Illustrative examples of model application for drug disposition.
- Simulation of drug-drug interactions in various patient populations.
Main Results:
- Successful implementation of a PBPK model in Matlab.
- Demonstration of PBPK model's utility in predicting drug disposition.
- Quantification of drug-drug interaction magnitudes across different populations.
Conclusions:
- Matlab provides a viable platform for building complex PBPK models.
- PBPK models are powerful tools for in silico prediction in special populations.
- This tutorial facilitates the use of PBPK modeling in drug development and clinical pharmacology research.
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