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Validating registry data on statins prescriptions by blood measurements
Anders H Riis1, Rune Erichsen1, Eva B Ostenfeld1
1Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.
Pharmacoepidemiology and Drug Safety
|February 20, 2019
Summary
This study validates prescription data for measuring statin adherence in colorectal cancer patients. Results show high adherence, confirming the reliability of prescription registries for tracking medication use.
Area of Science:
- Pharmacology
- Oncology
- Health Informatics
Background:
- Medication adherence is crucial for treatment efficacy, especially in chronic diseases like colorectal cancer.
- Accurate measurement of adherence is essential for evaluating treatment outcomes and optimizing patient care.
- Prescription data offers a potentially scalable method for assessing medication adherence.
Purpose of the Study:
- To validate the accuracy of prescription registry data against direct measurement of statin levels in blood.
- To assess the adherence to statin therapy in Danish colorectal cancer patients.
- To determine the positive and negative predictive values of prescription data for statin adherence.
Main Methods:
- Linked prescription data with two Danish colorectal cancer patient cohorts.
- Analyzed serial blood samples using statin assays to confirm drug presence.
- Calculated positive and negative predictive values using assay results as the gold standard.
Main Results:
- The study analyzed 73 statin-prescribed patients and 74 matched controls.
- Positive and negative predictive values for prescription data were both 93%.
- 71% of statin-prescribed patients showed statins in all blood samples, indicating continuous adherence.
Conclusions:
- Prescription registry data is a reliable tool for measuring statin adherence in colorectal cancer patients.
- High adherence rates were observed in this patient cohort.
- This validation supports the use of prescription data in clinical research and practice.
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