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Updated: Jan 29, 2026

A Micropatterning Assay for Measuring Cell Chirality
Published on: March 11, 2022
Practical and Scalable Kinetic Resolution of BINOLs Mediated by a Chiral Counterion
Benjamin A Jones1, Tudor Balan1, John D Jolliffe1
1Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK.
Abstract:
BINOLs are valuable and widely used building blocks, chiral ligands, and catalysts that are effective across a remarkable range of different chemical transformations. Here we demonstrate that an ammonium salt catalyzed kinetic resolution of racemic BINOLs with benzyl tosylate proceeds with s up to 46. This is a scalable and practical process that can be applied across >30 different C2 - and non-C2 -symmetric BINOLs. Implementation of this method enables the enantioselective synthesis of a wide range of BINOL derivatives with over 99:1 e.r.
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