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Updated: Jan 29, 2026

Efficient and Site-specific Antibody Labeling by Strain-promoted Azide-alkyne Cycloaddition
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Structural Distortion of Cycloalkynes Influences Cycloaddition Rates both by Strain and Interaction Energies

Trevor A Hamlin1, Brian J Levandowski2, Ayush K Narsaria1

  • 1Department of Theoretical Chemistry, Amsterdam Center for Multiscale Modeling (ACMM), Vrije Universiteit Amsterdam, De Boelelaan 1083, 1081 HV, Amsterdam, The Netherlands.

Chemistry (Weinheim an Der Bergstrasse, Germany)
|February 20, 2019
PubMed

Keywords:
alkynesazidescycloadditiondensity functional calculationsreaction mechanisms

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