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Related Experiment Video

Updated: Jan 29, 2026

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
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Association of Periodontitis with Oral Cancer: A Case-Control Study.

Y J Shin1,2, H W Choung2, J H Lee2,3

  • 11 Department of Preventive and Social Dentistry, School of Dentistry, Seoul National University, Seoul, Korea.

Journal of Dental Research
|February 20, 2019
PubMed
Summary
This summary is machine-generated.

Periodontitis significantly increases the risk of oral squamous cell carcinoma (OSCC). Managing gum disease may help reduce the likelihood of developing OSCC, especially in high-risk groups.

Keywords:
dentalepidemiologyhead and neck canceroral diseasesoral squamous cell carcinomaperiodontal diseases

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Area of Science:

  • Oral health
  • Oncology
  • Periodontology

Background:

  • Oral squamous cell carcinoma (OSCC) is a significant global health concern.
  • The association between periodontitis and OSCC requires further investigation, particularly in large cohort studies.
  • Understanding this link is crucial for developing effective prevention and treatment strategies.

Purpose of the Study:

  • To investigate the association between periodontitis and OSCC in a Korean population.
  • To explore variations in this association across different tumor locations and tumor-node-metastasis (TNM) stages.
  • To identify specific demographic or clinical factors that may modify the risk.

Main Methods:

  • A case-control study involving 146 OSCC cases and 278 matched controls from Korea.
  • Periodontitis was diagnosed based on alveolar bone loss from panoramic radiographs.
  • Multivariable conditional logistic regression was used to analyze the adjusted association, controlling for potential confounders.

Main Results:

  • Individuals with periodontitis were 3.7 times more likely to develop OSCC (aOR = 3.66).
  • The association was particularly strong in males, individuals over 60, and those with significant tooth loss.
  • No statistically significant differences in periodontitis prevalence were observed across different TNM stages or tumor locations.

Conclusions:

  • Periodontitis is an independent risk factor for OSCC.
  • Reducing the burden of periodontitis may offer a strategy to modulate OSCC risk.
  • Further research should focus on the mechanisms underlying this association and targeted interventions.