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Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis
Published on: May 16, 2025
Porous Polymeric Microparticles as an Oral Drug Platform for Effective Ulcerative Colitis Treatment
Xin Zhou1, Qiubing Chen1, Ya Ma1
1Education Ministry Key Laboratory on Luminescence and Real-Time Analysis, Institute for Clean Energy and Advanced Materials, School of Materials and Energy, Southwest University, Beibei, Chongqing 400715, P.R. China.
Abstract:
Porous microparticles (MPs) have been regarded as a promising vehicle for drug delivery. Herein, porous MPs and their counterparts (nonporous MPs) were produced by a conventional emulsion-solvent evaporation method in the presence and absence of ammonium bicarbonate, and curcumin was encapsulated into these MPs during the preparation process. The obtained MPs possessed desirable diameters of around 1.2 μm and negative zeta potentials of approximately -28 mV. It was found that the release rate of curcumin was remarkably increased with the introduction of pores in MPs. Furthermore, orally administered porous MPs achieved statistically significantly better therapeutic outcomes against ulcerative colitis mouse model induced by dextran sulfate sodium, in comparison to nonporous MPs. These findings confirmed that porous MPs could be served as a promising platform for the treatment of ulcerative colitis via oral route.
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