Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Power Expended by a Constant Force00:57

Power Expended by a Constant Force

9.2K
The relationship between work done and the time taken to do it can be explained using the concept of power. For example, several sprinters in a race may have the same velocity when they reach the finish line, therefore doing the same amount of work, but the winner does it in the least amount of time. Thus, power is defined as the rate of doing work. Since work can vary as a function of time, the average power is defined as the work done during a time interval, divided by the time interval.
9.2K
Creep in Concrete01:22

Creep in Concrete

1.2K
Creep refers to the time-dependent increase in strain under a sustained load, excluding other time-dependent deformations associated with shrinkage, swelling, and thermal expansion in concrete. The primary mechanism behind creep involves the loss of physically adsorbed water from the calcium silicate hydrate within the hydrated cement paste. This process is further exacerbated by concrete's non-linear stress-strain relationship, microcrack development in the interfacial transition zone, and...
1.2K
Factors Affecting Creep01:28

Factors Affecting Creep

452
In normal-weight aggregate concrete, the hardened cement paste is the primary contributor to creep, whereas the aggregates, being stiffer than the cement paste, are more resilient to stress-induced deformation. The stiffness of the aggregates is defined by their modulus of elasticity, and the more voluminous they are in the concrete, the less it will creep.
Further, the water/cement ratio is critical, as a lower ratio increases concrete strength, thus reducing creep. The strength of the...
452
Effects of Creep01:25

Effects of Creep

437
Creep in concrete, the gradual deformation under prolonged stress, significantly impacts the integrity of structures. For reinforced concrete beams, it can be a vital design consideration, as it increases deflection, sometimes necessitating additional design measures. In columns, especially slender ones under eccentric loads, creep can cause buckling, compromising their stability. However, creep can be beneficial in indeterminate structures by mitigating stresses that arise from shrinkage,...
437
Classification of Skeletal Muscle Fibers01:48

Classification of Skeletal Muscle Fibers

59.5K
Skeletal muscles continuously produce ATP to provide the energy that enables muscle contractions. Skeletal muscle fibers can be categorized into three types based on differences in their contraction speed and how they produce ATP, as well as physical differences related to these factors. Most human muscles contain all three muscle fiber types, albeit in varying proportions.
Slow-Twitch Muscle Fibers
Slow oxidative, muscle fibers appear red due to large numbers of capillaries and high levels of...
59.5K
Fibronectins Connect Cells with ECM01:25

Fibronectins Connect Cells with ECM

3.4K
Fibronectin is an adhesive glycoprotein present in the extracellular matrix of embryogenic and adult tissue. These molecules primarily aid in regulating cell motility and attachment. A fibronectin molecule is composed of two identical polypeptide chains attached to each other by a pair of disulfide bonds at the C-terminal.
Both proteoglycans and collagen are attached to fibronectin proteins, which, in turn, are attached to integrin proteins. These integrin proteins interact with transmembrane...
3.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

To the moon: Retail investor attention and sentiment across asset types in online media.

PloS one·2026
Same author

What a royal bedchamber provides the queen bee.

Nature·2026
Same author

Identifying Mechano-Modulators of Myometrial Contractility in a Scalable Hydrogel Culture Platform.

Tissue engineering. Part A·2026
Same author

Social media analysis reflects the negative sentiments experienced at both time changes with somewhat more depressive impact in early fall.

PloS one·2026
Same author

The mechanism of mammalian peroxidase destruction of invasive microbes.

PloS one·2026
Same author

Investigation of Peptide Binding to Fibrin for the Design of Targeted Molecular Imaging Agents.

Langmuir : the ACS journal of surfaces and colloids·2025

Related Experiment Video

Updated: Jan 29, 2026

Molecular Spring Constant Analysis by Biomembrane Force Probe Spectroscopy
08:10

Molecular Spring Constant Analysis by Biomembrane Force Probe Spectroscopy

Published on: November 20, 2021

3.4K

Fibronectin fiber creep under constant force loading.

Mark J Bradshaw1, Gwendolyn A Hoffmann2, Joyce Y Wong2

  • 1Department of Mechanical Engineering, Boston University, Boston, MA 02215, United States.

Acta Biomaterialia
|February 20, 2019
PubMed
Summary
This summary is machine-generated.

Extracellular matrix (ECM) fibers, like fibronectin (Fn), exhibit long-term stretching and permanent deformation under constant force. This mechanical behavior under sustained load may alter their biological functions.

Keywords:
Extracellular matrixFibronectinMechanotransductionViscoelasticity

More Related Videos

Stretching Short Sequences of DNA with Constant Force Axial Optical Tweezers
08:48

Stretching Short Sequences of DNA with Constant Force Axial Optical Tweezers

Published on: October 13, 2011

13.5K
Measurement of Maximum Isometric Force Generated by Permeabilized Skeletal Muscle Fibers
11:30

Measurement of Maximum Isometric Force Generated by Permeabilized Skeletal Muscle Fibers

Published on: June 16, 2015

26.3K

Related Experiment Videos

Last Updated: Jan 29, 2026

Molecular Spring Constant Analysis by Biomembrane Force Probe Spectroscopy
08:10

Molecular Spring Constant Analysis by Biomembrane Force Probe Spectroscopy

Published on: November 20, 2021

3.4K
Stretching Short Sequences of DNA with Constant Force Axial Optical Tweezers
08:48

Stretching Short Sequences of DNA with Constant Force Axial Optical Tweezers

Published on: October 13, 2011

13.5K
Measurement of Maximum Isometric Force Generated by Permeabilized Skeletal Muscle Fibers
11:30

Measurement of Maximum Isometric Force Generated by Permeabilized Skeletal Muscle Fibers

Published on: June 16, 2015

26.3K

Area of Science:

  • Biomaterials Science
  • Mechanobiology
  • Cell Biology

Background:

  • The extracellular matrix (ECM) is crucial for tissue structure and function.
  • Viscoelasticity is a key property of ECM fibers, influencing cellular processes.
  • Understanding ECM fiber response to long-term mechanical stress is vital but understudied.

Purpose of the Study:

  • To investigate the time-dependent mechanical response of single fibronectin (Fn) fibers under constant force loading.
  • To characterize the viscoelastic behavior and deformation of Fn fibers over extended periods (up to 8 hours).

Main Methods:

  • Development of a novel dual micropipette system for applying constant force to single ECM fibers.
  • Application of the system to measure the creep and deformation of individual fibronectin fibers under sustained load.

Main Results:

  • Fibronectin fibers exhibit continuous stretching (creep) under constant force for at least 8 hours.
  • Long-term creep leads to plastic deformation of fibronectin fibers, unlike short-term elastic deformation.
  • The creep behavior of fibronectin fibers under constant force loading follows a power law.

Conclusions:

  • Physiologically relevant, long-term mechanical loading can induce plastic changes in fibronectin fibers.
  • These mechanically induced alterations may switch fibronectin into a new functional state with potentially altered biological activities.
  • The mechanobiological switching of fibronectin may be a singular event following prolonged loading.