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Updated: Jan 29, 2026

Quantification of Protein Interaction Network Dynamics using Multiplexed Co-Immunoprecipitation
Published on: August 21, 2019
Dynamical complexity as a proxy for the network degree distribution
A Tlaie1,2,3, I Leyva1,2, R Sevilla-Escoboza4
1Complex Systems Group & GISC, Universidad Rey Juan Carlos, 28933 Móstoles, Madrid, Spain.
Abstract:
We explore the relation between the topological relevance of a node in a complex network and the individual dynamics it exhibits. When the system is weakly coupled, the effect of the coupling strength against the dynamical complexity of the nodes is found to be a function of their topological roles, with nodes of higher degree displaying lower levels of complexity. We provide several examples of theoretical models of chaotic oscillators, pulse-coupled neurons, and experimental networks of nonlinear electronic circuits evidencing such a hierarchical behavior. Importantly, our results imply that it is possible to infer the degree distribution of a network only from individual dynamical measurements.
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