Related Experiment Video

Updated: Jan 29, 2026

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory
10:03

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory

Published on: February 28, 2013

26.5K

Role of endothelial progenitor cells in diabetes mellitus

Angelo Avogaro1, Gian Paolo Fadini2

  • 1a Dipartimento di Medicina Clinica e Sperimentale, Cattedra di Malattie del Metabolismo, Università di Padova, Via Giustiniani 2, 35128 Padova, Italy. angelo.avogaro@unipd.it.

Expert Review of Endocrinology & Metabolism
|February 21, 2019
PubMed

Insights

Endothelial progenitor cells (EPCs) play a crucial role in vascular health. In diabetes, EPC dysfunction contributes to cardiovascular complications, highlighting their potential as disease biomarkers.

Area of Science:

  • Cardiovascular Biology
  • Endothelial Cell Biology
  • Diabetes Pathophysiology

Background:

  • Endothelial progenitor cells (EPCs) are vital for vascular repair and angiogenesis.
  • EPCs are integral to maintaining cardiovascular health.
  • Dysfunctional EPC biology is increasingly recognized in diabetes pathogenesis.

Purpose of the Study:

  • To explore the role of EPCs in the development of diabetic vascular complications.
  • To investigate EPCs as potential biomarkers for cardiovascular risk in diabetes.

Main Methods:

  • Review of current literature on EPC biology in diabetes.
  • Analysis of mechanisms underlying EPC dysfunction in diabetic patients.

Main Results:

  • Derangement of EPC biology is linked to micro- and macro-vascular complications in diabetes.
  • Defective EPC mobilization and reduced half-life are potential mechanisms of dysfunction.
  • EPCs serve as indicators of cardiovascular risk.

Conclusions:

  • EPC dysfunction is a significant factor in the pathogenesis of diabetic vascular complications.
  • EPCs offer a novel pathophysiological link to understand and potentially manage diabetic complications.

Keywords:
angiogenesiscardiovascular diseasecomplicationsdiabetesendothelial progenitor cellrisk factor

More Related Videos

Isolation of Endothelial Progenitor Cells from Human Umbilical Cord Blood07:26

Isolation of Endothelial Progenitor Cells from Human Umbilical Cord Blood

Published on: September 14, 2017

11.8K
Induction of Endothelial Differentiation in Cardiac Progenitor Cells Under Low Serum Conditions12:48

Induction of Endothelial Differentiation in Cardiac Progenitor Cells Under Low Serum Conditions

Published on: January 7, 2019

6.8K

Related Concept Videos

Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
4.7K
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
5.2K
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
3.5K
Role of Myosin in Cell Migration01:18

Role of Myosin in Cell Migration

Myosins are multimeric motor proteins involved in various cellular processes such as migration, adhesion, and proliferation. Myosin II is the most common type in animal cells, which binds and cross-links actin filaments.
Myosin II  is a hexamer comprising two heavy chains with globular heads and coiled-coil tails, two regulatory light chains, and two essential light chains. The ATPase sites on the myosin heads hydrolyze ATP, and the released phosphate generates the force for contraction....
3.3K
Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
4.0K
Role of Microtubules in Cell Wall Deposition01:02

Role of Microtubules in Cell Wall Deposition

Microtubules are small hollow tubes in eukaryotic cells. The cell wall microtubules are polymerized dimers of two globular proteins, α-tubulin and β-tubulin, two globular proteins. With a diameter of about 25 nm, microtubules are the widest components of the cytoskeleton. They help the cell resist compression and provide a track along which vesicles move through the cell or pull replicated chromosomes to opposite ends of a dividing cell. Microtubules go through quick cycles of...
3.1K