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Updated: Jan 29, 2026

Induction of Experimental Autoimmune Hypophysitis in SJL Mice
Published on: December 17, 2010
Autoimmune hypophysitis: expanding the differential diagnosis to CTLA-4 blockade
Angelika Gutenberg1, Melissa Landek-Salgado2, Shey-Cherng Tzou3
1a Department of Neurosurgery, Georg-August University, Goettingen, Germany. agutenberg@med.uni-goettingen.de.
Abstract:
Autoimmune hypophysitis is an increasingly recognized disorder that enters in the differential diagnosis of nonfunctioning pituitary masses. The differential diagnosis of these conditions is challenging because of similar clinical presentations and radiological signs. This review describes the essential features of hypophysitis and the other nonfunctioning pituitary masses. It also emphasizes a recently described feature of hypophysitis: its appearance with unexpectedly high frequency in patients receiving treatments that abrogate the function of cytotoxic T lymphocyte antigen 4.
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