Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Paget's disease of bone.

Brya Matthews1, Tim Cundy2

  • 1a Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, New Zealand. brya.matthews@auckland.ac.nz.

Expert Review of Endocrinology & Metabolism
|February 21, 2019
PubMed
Summary

Paget

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Skeletal fluorosis from excessive tea drinking.

Internal medicine journal·2026
Same author

20 years later: unravelling the genomic success of New Zealand's home-grown AK3 community-associated methicillin-resistant <i>Staphylococcus aureus</i>.

Microbial genomics·2025
Same author

Long-Term Denosumab Treatment in Adults with Juvenile Paget Disease.

Calcified tissue international·2025
Same author

Development of Paget's disease of bone in adults inheriting <i>SQSTM1</i> mutations: a long-term follow-up.

JBMR plus·2024
Same author

Idiopathic juvenile osteoporosis-a polygenic disorder?

JBMR plus·2024
Same author

Defining and Phenotyping Gastric Abnormalities in Long-Term Type 1 Diabetes Using a Novel Body Surface Gastric Mapping Device.

Gastro hep advances·2024

Area of Science:

  • Bone biology and pathology
  • Genetics and epidemiology of bone disorders

Background:

  • Paget's disease of bone is a common focal skeletal disorder in older Western European populations.
  • Despite effective treatments, its pathogenesis and natural history remain incompletely understood.
  • Recent advances in epidemiology, genetics, and molecular biology offer new insights.

Purpose of the Study:

  • To review outstanding problems in Paget's disease of bone.
  • To integrate current knowledge on its epidemiology, genetics, and molecular biology.
  • To explore how solving these problems may advance bone cell biology.

Main Methods:

  • Literature review of recent advances in Paget's disease of bone.
  • Synthesis of information on epidemiology, genetics, and molecular biology.
  • Examination of unresolved questions in pathogenesis and natural history.

Main Results:

  • Significant progress has been made in understanding the epidemiology, genetics, and molecular basis of Paget's disease.
  • Key aspects of pathogenesis and natural history require further investigation.
  • An integrated view incorporating all facets of the disease is still developing.

Conclusions:

  • Further research into Paget's disease of bone is crucial for a comprehensive understanding.
  • Solving outstanding problems will likely reshape our knowledge of bone cell biology.
  • Continued investigation into the disorder's pathogenesis and natural history is warranted.
Keywords:
Paget’s disease of bonebisphosphonatescell biologyepidemiologygeneticsnatural history

Related Experiment Videos