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Nonclassic congenital adrenal hyperplasia and the heterozygote carrier
Sara Ahmadi1, Saadia Alvi2, Randall J Urban3
1a Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Abstract:
This article discusses the difficulty of differentiating three causes of adult androgen excess including nonclassic congenital adrenal hyperplasia caused by 21-hydroxylase deficiency, polycystic ovarian syndrome and heterozygote carrier of CYP21 mutations based on clinical findings. It also reviews the screening modalities that discriminate patients with nonclassic congenital adrenal hyperplasia and the heterozygote carrier of CYP21 mutations from the normal population. In addition, the current management of hyperandrogenism and ovulatory dysfunction in these patients is described.
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