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Updated: Jan 29, 2026

Sexual Development and Ascospore Discharge in Fusarium graminearum
Published on: March 29, 2012
Hormonal abnormalities leading to disorders of sexual development
1a Division of Urology, University of Pennsylvania School of Medicine, The Children's Hospital of Philadelphia, 34th & Civic Center Boulevard, 3rd Floor Wood Building, Philadelphia, PA 19104, USA.
Abstract:
Normal human sexual development occurs in a highly regulated process that comprises three distinct phases: establishment of chromosomal sex, development of the sex-specific gonads and phenotypic differentiation of the internal ductal anatomy and external genitalia. The latter two phases are mediated by specific hormonal effector molecules, including anti-Müllerian hormone and testosterone, and their dysregulation often leads to the development of a phenotypic disorder of sexual differentiation. This review describes the hormonal mediators that are involved in sexual development and the disorders of sexual differentiation that arise from their dysfunction.
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