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Related Concept Videos

The Thyroid Gland01:23

The Thyroid Gland

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The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
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The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
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Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
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Impression Management Techniques I: Managing Appearances01:29

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Appearance is a multidimensional aspect of self-presentation that encompasses observable attributes such as clothing, grooming, speech, and nonverbal behavior. These elements are often strategically managed to align with socially constructed expectations in different settings. For instance, individuals tailor their appearance during job interviews, social gatherings, or athletic events to meet the perceived norms of those environments.Contextual Adaptation and Social SignalsThe research...
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Impression management encompasses individuals' deliberate efforts to shape how others perceive them during social interactions. This behavior is often employed to conform to social norms, secure approval, or pursue specific goals. While it involves selective self-presentation, it is not necessarily deceptive; individuals frequently present authentic aspects of themselves that align with situational demands.Common strategies include:Ingratiation: where individuals use flattery or agreeableness...
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Updated: Jan 29, 2026

An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma
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Managing anaplastic thyroid carcinoma.

Ejigayehu G Abate1, Robert C Smallridge1,2

  • 1a Division of Endocrinology, Department of Internal Medicine, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, USA.

Expert Review of Endocrinology & Metabolism
|February 21, 2019
PubMed
Summary
This summary is machine-generated.

Anaplastic thyroid cancer is a deadly malignancy with poor outcomes. Research is exploring genetic pathways and novel therapies, including multimodal treatments, to improve survival for this aggressive cancer.

Keywords:
anaplastic thyroid carcinomamultimodal treatmentsnovel therapypathogenesissignaling pathwaysstagingtargeted therapy

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Last Updated: Jan 29, 2026

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Area of Science:

  • Oncology
  • Genetics
  • Medical Research

Background:

  • Anaplastic thyroid cancer (ATC) is a highly lethal malignancy.
  • ATC has a dismal prognosis, with a median survival of 5-6 months.
  • Current treatments offer limited efficacy, and the cancer is resistant to multimodal therapies.

Purpose of the Study:

  • To review the pathophysiology of anaplastic thyroid cancer.
  • To summarize current treatment strategies for ATC.
  • To highlight advances in identifying genetic pathway alterations and novel targeted therapies.

Main Methods:

  • Conducted a PubMed search using relevant keywords for thyroid neoplasms.
  • Reviewed 1673 publications on anaplastic thyroid carcinoma.
  • Synthesized information on pathophysiology, treatments, and emerging therapies.

Main Results:

  • Significant advances have been made in understanding the genetic pathways involved in ATC.
  • Multiple novel therapies targeting these pathways are in clinical trials.
  • No single effective treatment exists, but multimodal approaches show promise.

Conclusions:

  • Further research into genetic aberrations is crucial for developing effective ATC treatments.
  • Novel targeted therapies hold potential for improving patient outcomes.
  • Multimodal treatment combinations remain a cornerstone of current management.