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Design and Evaluation of An Extended-Release Olmesartan Tablet Using Chitosan/Cyclodextrin Composites

Makoto Anraku1,2, Ryo Tabuchi3, Miwa Goto4

  • 1Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Nishi-ku, Kumamoto 860-0082, Japan. anraku@ph.sojo-u.ac.jp.

Pharmaceutics
|February 21, 2019
PubMed
Summary

New sustained-release olmesartan tablets, using sulfobutyl ether-β-cyclodextrin and spray-dried chitosan, show promise for hypertension treatment. This formulation offers improved drug delivery and enhanced antihypertensive effects in animal studies.

Keywords:
antihypertensive effectschitosanextend-releasematrix tabletsulfobutyl ether β-cyclodextrin

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