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Molecular Implications of Natriuretic Peptides in the Protection from Hypertension and Target Organ Damage

Speranza Rubattu1,2, Maurizio Forte3, Simona Marchitti4

  • 1Department of Clinical and Molecular Medicine, School of Medicine and Psychology, Sapienza University of Rome, 00189 Rome, Italy. rubattu.speranza@neuromed.it.

International Journal of Molecular Sciences
|February 21, 2019
PubMed

Insights

The natriuretic peptide (NP) system, including NPs and their receptors, plays a crucial role in regulating blood pressure and protecting against cardiovascular damage. Understanding these mechanisms offers insights into hypertension pathogenesis and treatment.

Area of Science:

  • Cardiovascular Physiology
  • Endocrinology
  • Molecular Medicine

Background:

  • Hypertension is a complex, multifactorial condition linked to cardiovascular damage.
  • Neurohormonal system abnormalities contribute to hypertension and cardiovascular remodeling.
  • The natriuretic peptide (NP) system offers protective mechanisms against hypertension and related conditions.

Purpose of the Study:

  • To review the molecular mechanisms of the NP system's impact on blood pressure regulation.
  • To summarize evidence on the NP system's role in hypertension development.
  • To discuss the protective effects of NPs against hypertensive target organ damage.

Main Methods:

  • Review of experimental studies in animal models.
  • Analysis of molecular mechanisms underlying NP system function.
  • Synthesis of evidence on NP system's role in human hypertension.

Main Results:

  • The NP system, comprising NPs, receptors, and convertases, is vital for blood pressure homeostasis.
  • Experimental studies highlight the NP system's critical role in hypertension development.
  • NPs demonstrate protective effects against cardiovascular damage associated with hypertension.

Conclusions:

  • The NP system is a key regulator of blood pressure and a target for managing hypertension.
  • Translational research on the NP system provides valuable insights into hypertension pathogenesis.
  • Understanding the NP system's protective role is crucial for preventing hypertensive target organ damage.

Keywords:
animal modelscardiac hypertrophygenetic variantshypertensionlinkage analysisnatriuretic peptidesstroke

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