Related Experiment Video

Updated: Jan 29, 2026

In Vivo Investigation of Antimicrobial Blue Light Therapy for Multidrug-resistant Acinetobacter baumannii Burn Infections Using Bioluminescence Imaging
09:29

In Vivo Investigation of Antimicrobial Blue Light Therapy for Multidrug-resistant Acinetobacter baumannii Burn Infections Using Bioluminescence Imaging

Published on: April 28, 2017

9.9K

Ventilator-Associated Pneumonia due to Drug-Resistant Acinetobacter baumannii: Risk Factors and Mortality Relation

Aušra Čiginskienė1, Asta Dambrauskienė2, Jordi Rello3,4,5,6,7

  • 1Department of Intensive Care, Medical Academy, Lithuanian University of Health Sciences, 50161 Kaunas, Lithuania. ausraciginskiene@yahoo.com.

Medicina (Kaunas, Lithuania)
|February 21, 2019
PubMed

Insights

Ventilator-associated pneumonia (VAP) caused by drug-resistant Acinetobacter baumannii has high mortality. Risk factors like higher SAPS II scores and longer hospital stays correlate with increased resistance, but mortality is not linked to resistance levels.

Area of Science:

  • * Infectious Diseases
  • * Critical Care Medicine
  • * Antimicrobial Resistance

Background:

  • * Ventilator-associated pneumonia (VAP) caused by Acinetobacter baumannii presents significant mortality and healthcare challenges.
  • * The relationship between multidrug-resistance (MDR) of A. baumannii strains and patient outcomes remains a subject of debate.
  • * Understanding risk factors and predictors of mortality in VAP due to drug-resistant A. baumannii is crucial for improving patient care.

Purpose of the Study:

  • * To investigate the association between risk factors for VAP and mortality with the drug resistance profiles of Acinetobacter baumannii.
  • * To identify independent predictors of in-hospital mortality in patients with VAP caused by drug-resistant A. baumannii.

Main Methods:

  • * A retrospective cohort study involving 60 patients with VAP due to drug-resistant A. baumannii in medical-surgical intensive care units (ICUs).
  • * Data collected over a two-year period included patient demographics, clinical scores (SAPS II, SOFA), length of stay, prior antibiotic use, and resistance profiles (MDR, XDR, pPDR).
  • * Binary logistic regression analysis was employed to determine independent predictors of in-hospital mortality.

Main Results:

  • * Prevalence of multidrug-resistant (MDR), extensively drug-resistant (XDR), and potentially pandrug-resistant (pPDR) A. baumannii was 13.3%, 68.3%, and 18.3%, respectively.
  • * Higher SAPS II scores, longer hospital length of stay (LOS) prior to ICU and mechanical ventilation (MV), and carbapenem use were associated with higher resistance profiles.
  • * Overall in-hospital mortality was 63.3%; female gender, SOFA score on ICU admission, and RBC transfusion were identified as independent predictors of mortality.

Conclusions:

  • * Increased VAP risk factors, including higher SAPS II scores and prolonged hospital/MV duration, correlate with more resistant A. baumannii strains.
  • * Carbapenem use prior to VAP is linked to the risk of MDR A. baumannii infections.
  • * While mortality in drug-resistant A. baumannii VAP is high, it is not directly associated with the specific resistance profile; female gender, SOFA score, and RBC transfusion are key mortality predictors.
Keywords:
A. baumanniidrug resistancemortalitypredictorsventilator-associated pneumonia (VAP)

More Related Videos

Murine Oropharyngeal Aspiration Model of Ventilator-associated and Hospital-acquired Bacterial Pneumonia04:32

Murine Oropharyngeal Aspiration Model of Ventilator-associated and Hospital-acquired Bacterial Pneumonia

Published on: June 28, 2018

12.5K
Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes08:58

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes

Published on: March 3, 2023

7.8K

Related Concept Videos

Relative Risk01:12

Relative Risk

Relative risk (RR) is a statistical measure commonly used in epidemiology to compare the likelihood of a particular event occurring between two groups. This metric is important for evaluating the relationship between exposure to a specific risk factor and the probability of a particular outcome. It plays a crucial role in medical research, public health studies, and risk assessment. Relative risk quantifies how much more (or less) likely an event is to occur in an exposed group compared to an...
2.1K
Resistivity01:22

Resistivity

When a voltage is applied to a conductor, an electrical field is generated, and charges in the conductor feel the force due to the electrical field. The current density that results depends on the electrical field and the properties of the material. In some materials, including metals at a given temperature, the current density is approximately proportional to the electrical field. In these cases, the current density can be modeled as:
4.5K
Resistance01:19

Resistance

When a current moves through any conductor, the conductor causes some level of difficulty for the current to flow. The measure of that difficulty is known as the resistance of the material and is represented by R. Every material has its own resistance. In the case of conductors, heat is emitted whenever a current passes through them. Resistance depends on the resistivity of the material. Resistivity is a characteristic of the material used to fabricate electrical components, whereas the...
5.9K
Equivalent Resistance01:16

Equivalent Resistance

In circuit analysis, situations often arise where resistors are neither in series nor parallel configurations. To tackle such scenarios, three-terminal equivalent networks like the wye (Y) (Figure 1 (a)) or tee (T) and delta (Δ) (Figure 1 (b)) or pi (π) networks come into play. These networks offer versatile solutions and are frequently encountered in various applications, including three-phase electrical systems, electrical filters, and matching networks.
976
Resistance and Conductance01:25

Resistance and Conductance

A conductor's DC resistance at a given temperature is influenced by its resistivity, length, and cross-sectional area. Resistivity is an inherent property of the conductor material, with annealed copper serving as the international standard for measurement. For instance, the resistivity of hard-drawn aluminum at 20 degrees Celsius is 61% of the standard conductivity of annealed copper.
Various factors impact the resistance of a conductor. Spiraling in stranded conductors increases their...
509
Rolling Resistance01:21

Rolling Resistance

When a solid cylinder rolls steadily on a rigid surface, the normal force applied by the surface on the cylinder is perpendicular to the tangent at the contact point. However, since no materials are entirely rigid, the surface's reaction to the cylinder involves a range of normal pressures.
For instance, imagine a hard cylinder rolling on a comparatively soft surface. The cylinder's weight compresses the surface beneath it. As the cylinder moves, the material in front of it slows down due to...
640