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Updated: Jan 29, 2026

Author Spotlight: Engineering Molecular Tools for Disease Detection and Imaging
Published on: December 8, 2023
hsa_circRNA_104597: a novel potential diagnostic and therapeutic biomarker for schizophrenia
Gaofeng Yao1,2, Wei Niu3, Xiaoli Zhu2
1Department of Psychology, The Affiliated Wuxi Mental Health Center of Nanjing Medical University, Wuxi, PR China.
Abstract:
Aim: To assess whether expression of circular RNAs (circRNAs) in peripheral blood mononuclear cells can serve as a biomarker for diagnosis and/or therapeutic response in people living with schizophrenia (SZ). Materials & methods: Differentially expressed circRNAs were screened via microarray in nine individuals living with SZ and nine healthy controls, then quantified using real-time quantitative reverse transcription PCR in SZ (n = 102) and healthy control (n = 103) groups. CircRNAs were re-assessed twice in 30 randomly selected individuals living with SZ after 4- and 8-week antipsychotic treatments. Results: Five circRNAs were differentially expressed between groups. Only hsa_circRNA_104597, which was downregulated in the SZ group, was significantly upregulated after 8-week treatment. Conclusion: Dysregulation of hsa_circRNA_104597 may serve as a novel potential diagnostic and therapeutic biomarker for SZ.
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