Related Experiment Video
Updated: Jan 29, 2026
08:24
Establishing a Swine Model of Post-myocardial Infarction Heart Failure for Stem Cell Treatment
Published on: May 25, 2020
7.4K
Tooth Loss Predicts Myocardial Infarction, Heart Failure, Stroke, and Death
H J Lee1, E K Choi1, J B Park2
11 Division of Cardiology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
Journal of Dental Research
|February 21, 2019
Summary
Tooth loss is linked to higher risks of heart attack, heart failure, stroke, and death. Even a few missing teeth increase cardiovascular disease risk, highlighting oral health
Area of Science:
- Cardiovascular epidemiology
- Oral health research
- Public health
Background:
- Oral health, specifically tooth loss, is increasingly recognized for its systemic health implications.
- Existing research suggests a link between poor oral hygiene and cardiovascular disease (CVD).
Purpose of the Study:
- To investigate the association between the number of missing teeth and the risk of major cardiovascular events and all-cause mortality.
- To determine if tooth loss is an independent risk factor for cardiovascular disease.
Main Methods:
- A large-scale Korean nationwide cohort study using data from 2007-2008.
- Follow-up of over 4.4 million subjects until 2016 for incident myocardial infarction (MI), heart failure (HF), stroke, and death.
- Multivariable analysis adjusted for cardiovascular risk, behavioral, and income factors.
Main Results:
- Cardiovascular events and mortality increased proportionally with the number of missing teeth.
- Tooth loss was identified as an independent risk factor for MI, HF, stroke, and all-cause mortality.
- Each missing tooth was associated with a 1-2% increase in risk for these outcomes, with a substantial increase for ≥5 missing teeth.
Conclusions:
- Tooth loss demonstrates a dose-dependent association with incident MI, HF, ischemic stroke, and all-cause death.
- The number of missing teeth can serve as a valuable clinical predictor for identifying individuals at higher cardiovascular risk.
- Maintaining oral health is crucial for mitigating cardiovascular disease risk.
Related Concept Videos
01:29Heart Failure II: Pathophysiology
872
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
872
01:17Pathophysiology of Heart Failure
3.5K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
3.5K
01:27Heart Failure I: Introduction
847
Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
847
01:22Heart Failure VI: Adjunct Therapies
314
Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
314
01:22Heart Failure Drugs: Diuretics
948
Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
948
01:30Heart Failure V: Medical Management
272
Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...
272