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Association between SRD5A2 polymorphism and hypospadias: a meta-analysis
Steroid 5a-reductase type-2 (SRD5A2) gene polymorphisms are linked to hypospadias. This meta-analysis confirms SRD5A2 as a risk factor, providing consistent evidence for its association with the condition.
Area of Science:
- Genetics
- Urology
- Molecular Biology
Background:
- Hypospadias is a common congenital condition.
- The role of Steroid 5a-reductase type-2 (SRD5A2) gene polymorphisms in hypospadias etiology is debated due to inconsistent findings.
Purpose of the Study:
- To conduct a comprehensive meta-analysis.
- To systematically review the association between SRD5A2 gene polymorphisms and hypospadias.
Main Methods:
- Searched PubMed and Embase databases.
- Performed Hardy-Weinberg equilibrium (HWE) tests for genotypic distribution.
- Analyzed single-nucleotide polymorphism (SNP) rs523349.
- Conducted sensitivity and Egger's tests for bias.
Main Results:
- Included 6 studies in the meta-analysis.
- Found significant associations between SRD5A2 gene polymorphisms (rs523349) and hypospadias.
- Sensitivity analysis confirmed result stability.
- Identified publication bias in specific comparison models.
Conclusions:
- SRD5A2 gene is associated with hypospadias.
- SRD5A2 gene polymorphisms are potential risk factors for hypospadias.
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