Related Experiment Video
Updated: Jan 29, 2026

Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia
Published on: February 17, 2023
Association between SRD5A2 polymorphism and hypospadias: a meta-analysis
Abstract:
Steroid 5a-reductase type-2 (SRD5A2) has been reported to be associated with hypospadias, but the available results are not consistent across studies. Therefore, we conducted a comprehensive meta-analysis to systematically review the association between SRD5A2 gene polymorphisms and hypospadias. Public databases PubMed and Embase were searched before March 1, 2016. Hardy-Weinberg equilibrium (HWE) tests were performed to identify genotypic distribution of single-nucleotide polymorphisms (SNPs) in samples. Among the distribution, we only performed analyses for one SNP (rs523349). The stability of the results was evaluated by sensitivity analysis. Additionally, Egger's test was performed to test a potential publication bias. A total of 6 studies were enrolled. The genotype frequencies were almost consistent with HWE. There were significant differences among SRD5A2 gene polymorphisms and the gene models of rs523349. The results of sensitivity analysis revealed that the results were not unduly influenced by any one study. There was a publication bias in mutational homozygote vs. Wild type homozygote (t = 5.4207, P = 0.0002) or wild type homozygote vs. heterozygote + wild type homozygote (t = 5.2649, P = 0.0002), but no evidence of publication bias was found in other models. SRD5A2 is associated with hypospadias, and SRD5A2 gene polymorphisms might be one of risk factors of hypospadias.
More Related Videos
06:26Meta-analysis of Voxel-Based Neuroimaging Studies using Seed-based d Mapping with Permutation of Subject Images SDM-PSI
Published on: November 27, 2019
08:36Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment
Published on: April 19, 2024
Related Concept Videos
Directing Effect of Substituents: meta-Directing Groups
Single Nucleotide Polymorphisms-SNPs
Association Areas of the Cortex
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
Associative Learning
Classical conditioning, also known...
Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
Somatosensory, Motor, and Association Cortex