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Updated: Jan 29, 2026
09:09
Description of a Swine Infant Model of Volume-Controlled Hemorrhagic Shock
Published on: November 3, 2023
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[Coagulation function and hemorrhagic diseases in preterm infants with different gestational ages]
Liang Gao1, Xin-Zhu Lin, Qian-Qian Wu
1Department of Neonatology, Xiamen Maternal and Child Health Care Hospital, Xiamen, Fujian 361000, China. gaoliang811@163.com.
Summary
Coagulation function matures with gestational age in preterm infants. Abnormal activated partial thromboplastin time (APTT) and D-dimer (DD) levels may predict hemorrhagic disease risk in these infants.
Area of Science:
- Neonatal Medicine
- Hematology
- Pediatric Coagulation
Background:
- Preterm infants often exhibit immature coagulation systems.
- Hemorrhagic diseases are a significant concern in preterm neonates.
Purpose of the Study:
- To investigate the relationship between gestational age and coagulation function in preterm infants.
- To assess the predictive value of coagulation parameters for hemorrhagic diseases in preterm neonates.
Main Methods:
- Collected clinical data from preterm infants hospitalized between September 2016 and August 2017.
- Measured coagulation indicators within 2 hours of birth.
- Classified infants into late, early, and extremely/very early preterm groups based on gestational age.
Main Results:
- Significant differences in thrombin time (TT), prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen degradation product (FDP), and D-dimer (DD) were observed across gestational age groups.
- APTT, PT, FDP, and DD showed negative correlations with gestational age, while TT showed a positive correlation.
- Preterm infants with hemorrhagic diseases exhibited longer APTT and higher DD levels compared to those without.
Conclusions:
- Coagulation function demonstrates progressive maturation with increasing gestational age in preterm infants.
- Elevated APTT and DD levels are associated with an increased risk of hemorrhagic diseases in preterm neonates.
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