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Drug interactions of cola-containing drinks
Homa Nomani1, Ali Tafazoli Moghadam2, Seyed Ahmad Emami3
1School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Clinical Nutrition (Edinburgh, Scotland)
|February 21, 2019
Summary
Cola-containing drinks (CCDs) can interact with medications, affecting their absorption, metabolism, and excretion. These interactions, driven by acidity and caffeine, can lead to toxic or reduced drug efficacy, necessitating clinical awareness.
Area of Science:
- Pharmacology
- Drug Interactions
- Toxicology
Background:
- Cola-containing drinks (CCDs) are globally prevalent beverages.
- Existing literature highlights some drug interactions with CCDs.
- A comprehensive review of reported and potential CCD interactions is lacking.
Purpose of the Study:
- To provide a comprehensive review of reported and potential interactions between cola-containing drinks and various medications.
- To elucidate the mechanisms underlying these interactions, focusing on acidity and caffeine content.
- To inform clinicians about potential adverse drug reactions and efficacy changes.
Main Methods:
- Literature review of reported interactions between CCDs and pharmaceuticals.
- Analysis of proposed mechanisms involving CCD acidity and caffeine.
- Synthesis of data on pharmacokinetic and pharmacodynamic alterations.
Main Results:
- Increased serum concentrations of methotrexate (MTX), clozapine, carbamazepine, phenytoin, and ibuprofen.
- Decreased serum levels and efficacy of lithium and warfarin.
- Elevated serum concentrations of erlotinib, itraconazole, posaconazole, and ketoconazole.
Conclusions:
- CCDs possess the potential to interact with a wide range of drugs.
- Clinicians must be aware of both reported and potential CCD-drug interactions.
- Awareness is crucial for preventing adverse events and ensuring therapeutic efficacy.
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