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T-cell Activity against AML Improved by Dual-Targeted T Cells Stimulated through T-cell and IL7 Receptors

Eric Krawczyk1, Sergey N Zolov1, Kevin Huang1

  • 1Department of Pediatrics and Communicable Diseases, Division of Pediatric Hematology and Oncology, University of Michigan, Ann Arbor, Michigan.

Cancer Immunology Research
|February 21, 2019
PubMed
Summary

Engineered T cells targeting acute myeloid leukemia (AML) show promise. Dual-targeting T cells (CLEC12A-ENG.CD123IL7Rα) enhance AML killing and antitumor activity, improving treatment potential.

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