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Related Concept Videos

Actin Filament Depolymerization01:19

Actin Filament Depolymerization

3.9K
Actin filaments (F-actin) are composed of actin subunits. The dissociation of actin monomers can occur from either end of F-actin. The rate of dissociation is faster from the minus-end or the pointed end, where the actin subunits exist with a bound ADP, together known as ADP-actin. The depolymerization of F-actin is aided by proteins, including the actin-depolymerizing factor (ADF) and cofilin family of proteins, gelsolin, and glia maturation factor (GMF).
In F-actin, the ADF/cofilin proteins...
3.9K
Formation of Higher-order Actin Filaments01:11

Formation of Higher-order Actin Filaments

3.6K
The polymerization of G-actin monomers into filamentous F-actin is a multi-step process. Once the F-actins are formed, they can bundle together in different arrangements to form higher-order networks and regulate cellular functions. Common examples include the formation of lamellipodia and filopodia at the cell's leading edge by actin reorganization in a migrating cell. The microvilli on the brush border epithelial cells are also formed through the F-actin network.
The high-order actin...
3.6K
Generation of Straight or Branched Actin Filaments01:14

Generation of Straight or Branched Actin Filaments

3.8K
The straight or branched structure formation of actin filaments is controlled by nucleating proteins such as the formins and Arp2/3 complex. Formin-mediated assembly results in straight filaments, whereas Arp2/3 protein complex-mediated assembly results in branched actin filaments.
Arp2/3 Complex
Arp2/3 complex is a seven-subunit complex consisting of two proteins similar to actin- Arp2 and Arp3, and five other subunits that help keep Arp2 and Arp3 inactive. When required, the complex is...
3.8K
Conformity01:20

Conformity

48.2K
Conformity is the change in a person’s behavior to go along with the group, even if that person does not agree with the group.
48.2K
Expected Value01:15

Expected Value

7.8K
The expected value is known as the "long-term" average or mean. This means that over the long term of experimenting over and over, you would expect this average. The expected average is represented by the symbol μ. It is calculated as follows:
7.8K
Nucleotide Excision Repair01:08

Nucleotide Excision Repair

40.8K
Overview
40.8K

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Mechanisms of disassembly at the actin filament pointed and barbed ends.

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Mechanisms of CARMIL dimerization, autoinhibition, and capping protein binding.

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Related Experiment Video

Updated: Jan 28, 2026

Quantification of Filamentous Actin F-actin Puncta in Rat Cortical Neurons
10:13

Quantification of Filamentous Actin F-actin Puncta in Rat Cortical Neurons

Published on: February 10, 2016

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Nucleotide-dependent conformational changes in the actin filament: Subtler than expected

Roberto Dominguez1

  • 1Department of Physiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104 droberto@pennmedicine.upenn.edu.

Proceedings of the National Academy of Sciences of the United States of America
|February 21, 2019
PubMed
Summary

No abstract available in PubMed .

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