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Sulphur compounds used in medicine.
1Glaxo Group Research Ltd., Greenford, Middlesex.
Drug Metabolism and Drug Interactions
|January 1, 1988
Summary
Sulfur is crucial in drug development, appearing in various forms within many medications. Organosulfur compounds represent a significant therapeutic resource with untapped potential for future drug discovery.
Area of Science:
- Medicinal Chemistry
- Pharmacology
- Organic Chemistry
Background:
- Native sulfur has limited medicinal applications.
- Sulfur is a key element in numerous drug classes.
- Sulfur-containing compounds are vital in modern medicine.
Purpose of the Study:
- To highlight the significance of sulfur in drug molecules.
- To explore the diverse roles of sulfur in medicinal agents.
- To emphasize the therapeutic potential of organosulfur compounds.
Main Methods:
- Review of drug structures containing sulfur.
- Analysis of sulfur's oxidative states and organic combinations in pharmaceuticals.
- Examination of drug development strategies involving sulfur.
Main Results:
- Sulfur is present in drugs across all oxidative states and organic forms.
- Sulfur-containing compounds are integral to diverse drug classes, including dyes and antibiotics.
- Many clinically useful drugs incorporate sulfur.
Conclusions:
- Organosulfur compounds are a major therapeutic resource.
- The therapeutic potential of sulfur in drug design remains largely unexploited.
- Further research into sulfur-containing molecules is warranted for novel drug development.