Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Sulphoconjugation and sulphohydrolysis.

G M Powell¹, G F White, C G Curtis

¹Department of Biochemistry, University of Wales College of Cardiff, U.K.

Drug Metabolism and Drug Interactions

|January 1, 1988

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Imaging features of intraosseous hemangiomas: beyond the mobile spine and calvarium.

Skeletal radiology·2023

Same author

Radiographic and MRI Assessment of the Thrower's Elbow.

Current reviews in musculoskeletal medicine·2021

Same author

Sonographic evaluation of the lateral femoral cutaneous nerve in meralgia paresthetica.

Skeletal radiology·2020

Same author

Mechanisms of Bacterial Extracellular Electron Exchange.

Advances in microbial physiology·2016

Same author

Colonization of biofilms by bacteria capable of biodegrading sodium dodecyl sulphate (SDS) at clean and polluted riverine sites.

Microbial ecology·2013

Same author

Functional contribution of T1 to the brachial plexus in infants.

The Journal of hand surgery, European volume·2011

Same journal

CYP 2C19 and UDP-glucuronosyltransferases not only for drugs but also for endobiotics.

Drug metabolism and drug interactions·2014

Same journal

In vitro inhibitory effects of herbal supplements on tamoxifen and irinotecan metabolism.

Drug metabolism and drug interactions·2014

Same journal

Effect of silymarin pretreatment on the bioavailability of domperidone in healthy human volunteers.

Drug metabolism and drug interactions·2014

Same journal

Systems Medicine in the era of 'Big Data': a game-changer for Personalized Medicine?

Drug metabolism and drug interactions·2014

Same journal

The pharmacogenetics of carboxylesterases: CES1 and CES2 genetic variants and their clinical effect.

Drug metabolism and drug interactions·2014

Same journal

Effect of selective cyclooxygenase-2 inhibitor lumiracoxib on phenolsulfonphthalein disposition in rats.

Drug metabolism and drug interactions·2014

See all related articles

Sulphoconjugation and sulphohydrolysis are key metabolic processes involving sulphotransferases and sulphohydrolases. This review explores their roles in xenobiotic metabolism and the broader sulphur cycle.

Area of Science:

Biochemistry
Pharmacology
Microbiology

Background:

Sulphoconjugation is a widespread process modifying molecule properties and functions.
Sulphotransferases catalyze sulphate addition, while sulphohydrolases reverse this reaction.
Diverse sulphoconjugates are formed from endogenous and exogenous compounds.

Purpose of the Study:

To review sulphoconjugation and sulphohydrolysis in xenobiotic metabolism.
To discuss sulphur availability and the sulphate cycle.
To explore mammalian and microbial enzyme interactions in sulphur metabolism.

Main Methods:

Literature review and critical appraisal.
Analysis of enzyme families: sulphotransferases and sulphohydrolases.
Examination of metabolic pathways and the sulphur cycle.

Related Experiment Videos

Main Results:

Sulphoconjugation and sulphohydrolysis significantly impact xenobiotic metabolism.
Sulphur availability influences the efficiency of these enzymatic processes.
Mammalian and microbial systems exhibit complex interplay in the sulphate cycle.

Conclusions:

Understanding sulphoconjugation and sulphohydrolysis is crucial for xenobiotic metabolism.
The sulphur cycle involves intricate mammalian-microbial enzyme interactions.
Further research into sulphur metabolism can inform drug development and environmental science.