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Effects of traditional Chinese exercise on cardiac rehabilitation after percutaneous coronary intervention: study
Chuanjin Luo1, Junmao Wen2, Weipeng Sun2
1Department of Cardiovascular Disease, First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
Insights
Traditional Chinese exercise (TCE) may improve outcomes for patients after percutaneous coronary intervention (PCI). This network meta-analysis compares TCE, including tai chi, baduanjin, and yijinjing, within cardiac rehabilitation programs.
Area of Science:
- Cardiology
- Integrative Medicine
- Evidence-Based Practice
Background:
- Coronary heart disease (CHD) remains a leading cause of global mortality.
- Percutaneous coronary intervention (PCI) reduces CHD mortality but recurrences occur.
- Cardiac rehabilitation (CR) improves outcomes, and Traditional Chinese Exercise (TCE) shows promise post-PCI.
Purpose of the Study:
- To conduct a network meta-analysis on the effects of TCE in patients post-PCI.
- To compare the efficacy of tai chi, baduanjin, and yijinjing within CR after PCI.
Main Methods:
- Systematic literature search of multiple databases (PubMed, Embase, Cochrane, etc.) up to December 2018.
- Inclusion of randomized controlled trials evaluating TCE therapies in post-PCI patients.
- Bayesian network meta-analysis to pool data and assess treatment rankings using GRADE.
Main Results:
- Primary outcomes include all-cause mortality, revascularization, quality of life, and hospitalizations.
- Data extraction and risk of bias assessment by two independent reviewers.
- Estimation of ranking probabilities for optimal TCE interventions.
Conclusions:
- This study will provide consolidated evidence on the role of TCE in CR for post-PCI patients.
- Findings will inform clinical practice regarding the application of TCE in cardiac recovery.
Introduction:
Coronary heart disease (CHD) is the most common cause of death worldwide. Percutaneous coronary intervention (PCI) has been shown to reduce mortality in patients with CHD. However, there are still recurrences of cardiovascular events after PCI. Cardiac rehabilitation (CR) in patients with established CHD is associated with reductions in cardiovascular mortality and hospital admissions, as well as improved quality of life. More and more clinical trials suggest that traditional Chinese exercise (TCE) plays a positive role in patients post-PCI. The primary purposes of the current study are to conduct a network meta-analysis of randomised trials to determine the effects of TCE in patients after PCI, and to separately compare the effects of tai chi, baduanjin and yijinjing on CR after PCI.
Methods And Analysis:
Studies will be retrieved from the following databases: PubMed, Embase, Cochrane Library, Chinese National Knowledge Infrastructure, Wanfang Data, Chinese BioMedical Database and Chinese Science and Technology Periodicals Database, from inception to December 2018. We will include randomised controlled trials that are related to the effects of TCE therapies in patients after PCI. The primary outcomes will be all-cause mortality, revascularisations, health-related quality of life and hospitalisations. Two reviewers will independently select eligible articles. For each included article, two reviewers will independently extract the data and assess the risk of bias by using the Cochrane risk of bias tool. Bayesian network meta-analyses will be conducted to pool all treatment effects. The ranking probabilities for the optimal intervention of various treatments (tai chi, baduanjin or yijinjing) will be estimated by the mean ranks and surface under the cumulative ranking curve. The Grading of Recommendations Assessment, Development and Evaluation System will be used to assess the quality of evidence.
Ethics And Dissemination:
The results will be disseminated through peer-reviewed publications. They will provide consolidated evidence to inform clinicians on the potential functions of TCE in CR, and to provide reliable evidence for the application of TCE.
Trial Registration Number:
CRD42018088415.
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