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Delivery Technologies for Orally Inhaled Products: an Update
Chaeho Moon1, Hugh D C Smyth1, Alan B Watts1
1College of Pharmacy, The University of Texas at Austin, 2409 West University Avenue, PHR 4.214, Austin, Texas, 78712, USA.
AAPS Pharmscitech
|February 21, 2019
Summary
New formulations and devices improve orally inhaled products by addressing challenges like low lung deposition and variable dosing. These advancements enhance drug delivery efficiency and patient compliance for pulmonary and systemic treatments.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Technologies
- Pulmonary Medicine
Background:
- Orally inhaled products offer benefits for local pulmonary disease treatment and systemic drug delivery, including rapid absorption and avoidance of first-pass metabolism.
- Key challenges persist, such as inconsistent lung drug deposition, dosing limitations, and significant drug deposition in the oropharynx.
- These limitations necessitate innovation in drug delivery systems for inhaled medications.
Purpose of the Study:
- To review advancements in orally inhaled product technologies.
- To highlight how new formulations and devices overcome existing challenges in drug delivery to the lungs.
- To discuss the impact of these innovations on therapeutic efficacy and patient compliance.
Main Methods:
- Review of recent developments in formulation science for inhaled products.
- Analysis of emerging device technologies for optimizing aerosol generation and lung deposition.
- Synthesis of data on particle engineering (density, size, shape, surface energy) and device design improvements.
- Examination of strategies to minimize patient errors and enhance usability.
Main Results:
- Formulation advancements enable better control over particle properties, leading to improved aerosolization.
- New device technologies focus on enhancing delivery efficiency, dose consistency, and expanding the range of treatable conditions.
- Innovations aim to reduce oropharyngeal deposition and increase drug delivery to the lungs.
- Improved technologies have the potential to significantly increase patient compliance and therapeutic outcomes.
Conclusions:
- New formulations and device technologies are crucial for overcoming the limitations of current orally inhaled products.
- These advancements promise more effective and reliable drug delivery for both local and systemic treatments via inhalation.
- The integration of improved formulations and devices is key to enhancing patient compliance and treatment success in pulmonary medicine.
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