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Lymphoma diagnostics: getting more from less.

Paul J Galardy1,2,3, Tibor Bedekovics1, Elizabeth Macintyre4

  • 1Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.

British Journal of Haematology
|February 21, 2019
PubMed
Summary
This summary is machine-generated.

Diagnosing lymphoma is challenging with minimal tissue. Liquid biopsies, analyzing circulating tumor cells, DNA, and exosomes in blood, offer promising solutions for diagnosis, prognosis, and treatment monitoring in lymphoma patients.

Keywords:
cell-free DNAcirculating tumour cellsexosomesminimal disseminated diseasenon-Hodgkin lymphoma

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Area of Science:

  • Hematology
  • Oncology
  • Molecular Diagnostics

Background:

  • Minimally invasive procedures for lymphoma diagnosis yield limited tissue, complicating histopathological assessment and molecular testing.
  • The need for larger tissue samples for research conflicts with the trend towards less invasive diagnostic methods.
  • Emerging liquid biopsy techniques analyze circulating biomarkers in blood for lymphoma diagnosis and research.

Purpose of the Study:

  • To review recent advancements in liquid biopsy for lymphoma diagnosis, prognosis, and therapeutic monitoring.
  • To explore the utility of circulating tumor cells, circulating tumor DNA, and exosomes in lymphoma management.
  • To highlight how liquid biopsies can bridge the gap between clinical care and research needs.

Main Methods:

  • Review of current literature on liquid biopsy techniques in lymphoma.
  • Analysis of data concerning circulating tumor cells (CTCs) for diagnostic and prognostic value.
  • Evaluation of circulating tumor DNA (ctDNA) and exosomes for their role in lymphoma assessment.

Main Results:

  • Liquid biopsies provide valuable diagnostic and prognostic information from blood samples.
  • Circulating tumor cells, ctDNA, and exosomes show potential for non-invasive lymphoma detection and monitoring.
  • These biomarkers aid in understanding lymphoma biology and genetics, facilitating research.

Conclusions:

  • Liquid biopsies offer a promising alternative to traditional tissue biopsies for lymphoma diagnosis and management.
  • Advancements in analyzing circulating biomarkers support both safe patient care and the progression of translational research.
  • The integration of liquid biopsies is expected to enhance personalized medicine approaches in lymphoma treatment.