Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neurogenic inflammation.

B Lynn1

  • 1Department of Physiology, University College, London, UK.

Skin Pharmacology : the Official Journal of the Skin Pharmacology Society
|January 1, 1988
PubMed
Summary
This summary is machine-generated.

Neurogenic inflammation involves skin responses like vasodilatation and plasma extravasation. New evidence suggests both myelinated and unmyelinated nerve fibers contribute to these inflammatory processes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Interdigitated coplanar electrodes for enhanced sensitivity in a photorefractive polymer.

Optics letters·2011
Same author

Longitudinal sliding of the median nerve in patients with carpal tunnel syndrome.

Journal of hand surgery (Edinburgh, Scotland)·2003
Same author

The use of cross-correlation analysis between high-frequency ultrasound images to measure longitudinal median nerve movement.

Ultrasound in medicine & biology·2001
Same author

The use of ultrasound imaging to demonstrate reduced movement of the median nerve during wrist flexion in patients with non-specific arm pain.

Journal of hand surgery (Edinburgh, Scotland)·2001
Same author

Acute traumatic myelopathy secondary to a thoracic cyst in a professional football player.

Spine·2000
Same author

Schwann cell-derived Desert hedgehog controls the development of peripheral nerve sheaths.

Neuron·1999

Area of Science:

  • Neuroscience
  • Dermatology
  • Immunology

Background:

  • Neurogenic inflammation is a key component of skin responses.
  • Key elements include antidromic vasodilatation, axon reflex flare, and plasma extravasation.

Purpose of the Study:

  • To describe the main elements of neurogenic inflammation in the skin.
  • To present new evidence on the contribution of nerve fibers to antidromic vasodilatation.
  • To discuss the mechanisms and implications of neurogenic inflammation in various conditions.

Main Methods:

  • Review of existing literature on neurogenic inflammation.
  • Presentation of new experimental evidence.
  • Discussion of theoretical mechanisms underlying neurogenic flare and vasodilatation spread.

Related Experiment Videos

Main Results:

  • Small myelinated fibers, alongside unmyelinated fibers, contribute to antidromic vasodilatation.
  • Weak coupling between C-fibre terminals is crucial for the spread of vasodilatation.
  • Neurogenic mechanisms may be more significant in inflammatory models and diseases than previously thought.

Conclusions:

  • Neurogenic inflammation plays a substantial role in skin inflammatory responses.
  • The contribution of both myelinated and unmyelinated fibers to neurogenic inflammation is significant.
  • The importance of neurogenic mechanisms in inflammatory conditions may be underestimated.