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Factor XI and recurrent venous thrombosis: an observational cohort study
Paul A Kyrle1,2, Lisbeth Eischer1, Hana Šinkovec3
1Department of Medicine I, Medical University of Vienna, Vienna, Austria.
Journal of Thrombosis and Haemostasis : JTH
|February 21, 2019
Summary
Low factor XI activity significantly reduces the risk of recurrent venous thrombosis. This finding supports factor XI (FXI) as a promising target for developing new anticoagulation therapies.
Area of Science:
- Cardiovascular Medicine
- Hematology
- Thrombosis Research
Background:
- Factor XI (FXI) is recognized as a potential target for anticoagulation therapy.
- Low factor XI activity (FXIa) has been suggested to reduce the risk of venous thromboembolism (VTE).
Purpose of the Study:
- To investigate the association between FXIa and the risk of recurrent VTE in patients who have stopped anticoagulation.
- To explore the relationship between FXIa and D-dimer levels as an indicator of hemostatic system activation.
Main Methods:
- A cohort study involving 851 patients with unprovoked VTE after cessation of anticoagulation.
- Analysis of recurrent VTE events and measurement of FXIa and D-dimer levels.
- Statistical adjustments for age and sex were applied.
Main Results:
- Lower FXIa was significantly associated with a reduced risk of VTE recurrence.
- Patients with FXIa below the 34th percentile had a significantly lower probability of recurrence (P=0.029).
- A significant inverse linear association was found between FXIa and D-dimer levels.
Conclusions:
- Findings support the hypothesis that FXI plays a role in thrombosis.
- Low FXIa is linked to both reduced thrombosis risk and less hemostatic activation.
- Factor XI represents a promising therapeutic target for anticoagulation.
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