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A case of treatable dementia with Lewy bodies remarkably improved by immunotherapy

Kie Abe1, Yuhei Chiba1

  • 1Department of Psychiatry, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-Ku, Yokohama-Shi, Kanagawa-Ken 236-0004, Japan.

Journal of Neuroimmunology
|February 21, 2019
PubMed

We report a case of probable dementia with Lewy bodies (DLB) with several findings indicating autoimmune encephalitis (e.g. anti-thyroid antibodies in serum and oligoclonal band and anti-N-methyl-d-aspartic acid receptor antibodies in cerebrospinal fluid). The symptoms and the findings of ancillary tests such as Iodine-123-metaiodobenzylguanidine myocardial scintigraphy and 99mTechnetium-ethyl-cysteinate-dimer single photon emission computed tomography were improved after the pulse and oral steroid treatment. This case is thought the autoimmune encephalitis mimicking DLB. This experience indicated the importance of suspecting treatable DLB even when the findings of laboratory and radiological tests fulfill the diagnostic criteria of DLB.

Keywords:
Anti-N-methyl-d-aspartic acid receptor antibodyAnti-thyroid antibodyAutoimmune encephalitisDementia with Lewy bodiesNeuroinflammationTreatable dementia

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