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Updated: Jan 28, 2026

Radiosensitivity of Cancer Stem Cells in Lung Cancer Cell Lines
Published on: August 21, 2019
Patterns of care and survival outcomes for laryngeal small cell cancer
Alexander J Lin1, Prashant Gabani1, Ben Fischer-Valuck1
1Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri.
Background:
To determine practice patterns and outcomes of laryngeal small cell cancer (LSCC) across the United States.
Methods:
Patients with LSCC were identified in the National Cancer Database. Overall survival (OS) was compared with Kaplan-Meier analysis and Cox regression.
Results:
From 2004 to 2014, the 5-year OS for early stage (n = 47), locally advanced stage (n = 133), and metastatic disease (n = 53) was 34%, 26%, and 9%, respectively. Chemoradiation was given in 66% of cases. Chemotherapy was less likely given in early stage disease (P = .001), and definitive radiation was less likely given in metastatic disease (P < .001). Definitive radiation improved median OS in locally advanced LSCC (20 vs. 7 months, log-rank P = .04). In multivariable modeling, radiation dose ≥40 Gy was associated with better OS (P < .001).
Conclusion:
Chemoradiation was the most common practice for treating locally advanced LSCC, and radiation dose ≥40 Gy was associated with improved OS.
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