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Current and emerging pharmacotherapy for the treatment of infections following open-heart surgery

Daniele Roberto Giacobbe1, Silvia Corcione2, Antonio Salsano3,4

  • 1a Dipartimento di Scienze della Salute (DISSAL) , University of Genoa , Genoa , Italy.

Expert Opinion on Pharmacotherapy
|February 21, 2019
PubMed
Abstract

Insights

Choosing antimicrobials for open-heart surgery patients requires careful consideration of infection site, pathogen susceptibility, and drug pharmacokinetics to prevent complications. This review covers current and future antimicrobial strategies for these complex infections.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Pharmacology

Background:

  • Open-heart surgery patients are at high risk for severe postoperative infections.
  • Antimicrobial selection is complex due to infection site, pathogen resistance, and drug properties.

Purpose of the Study:

  • To review current and future antimicrobial options for treating infections after open-heart surgery.
  • To address challenges in antimicrobial therapy for cardiac surgery patients.

Main Methods:

  • Narrative review of existing literature.
  • Analysis of antimicrobial treatment strategies.

Main Results:

  • Empirical therapy is crucial for severe infections like bloodstream infections and deep sternal wounds.
  • Multidrug-resistant pathogens pose a significant threat in endemic areas.

Conclusions:

  • Multidisciplinary collaboration between infectious diseases specialists and cardiothoracic surgeons is essential.
  • Balancing risks and benefits of pharmacotherapy and potential reintervention is critical.
Keywords:
Cardiac surgeryDSWIVAPbloodstream infectionscardiothoracic surgeryendocarditisinfectionsopen heart surgerysternal wound infections

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