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Updated: Jan 28, 2026

Synthesis and Purification of Iodoaziridines Involving Quantitative Selection of the Optimal Stationary Phase for Chromatography
Published on: May 16, 2014
Core-Shell Metal-Organic Frameworks as the Mixed-Mode Stationary Phase for Hydrophilic Interaction/Reversed-Phase
Xueyun Li1, Bo Li1, Mingchen Liu1
1College of Pharmacy, Hebei Province Key Laboratory of Analytical Science & Technology, MOE Key Laboratory of Medicinal Chemistry & Molecular Diagnosis , Hebei University , Baoding 071002 , China.
Abstract:
Stationary phases with mixed-mode mechanisms have emerged as a hot research topic. In the present research, monodisperse core-shell UiO-67@SiO2 materials were prepared and further served as the packed column for mixed-mode hydrophilic interaction liquid chromatography/reversed-phase liquid chromatography. The developed UiO-67@SiO2 materials were characterized via thermogravimetric analysis, scanning electron microscopy, X-ray Powder diffraction, and Fourier transform infrared techniques. The developed UiO-67@SiO2 column shows flexible selectivity for separation of both hydrophobic (anilines, alkylbenzenes, and polycyclic aromatic hydrocarbons) and hydrophilic (thioureas) compounds. Furthermore, the UiO-67@SiO2 column was also utilized to characterize potential pollutants in lake water samples. In summary, the UiO-67@SiO2 column provided flexible selectivity and wide-range retention behaviors for both hydrophilic and hydrophobic analytes.
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