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Progress toward Understanding the Interactions between DNA Nanostructures and the Cell.

Yee Ting Elaine Chiu1, Huize Li1, Chung Hang Jonathan Choi1

  • 1Department of Biomedical Engineering, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong.

Small (Weinheim an Der Bergstrasse, Germany)
|February 21, 2019
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Summary
This summary is machine-generated.

DNA nanostructures offer biocompatible intracellular delivery. Recent studies reveal mechanisms of cellular uptake, trafficking, and degradation for tile-, origami-, and nanoparticle-templated DNA nanostructures.

Keywords:
DNA nanotechnologybio-nano interactionsnanomedicine

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Area of Science:

  • Biotechnology
  • Nanotechnology
  • Cell Biology

Background:

  • DNA nanotechnology enables precise assembly of DNA nanostructures.
  • These structures are biocompatible and can enter mammalian cells without transfection agents.
  • Applications in therapeutic and imaging cargo delivery have been established for over a decade.

Purpose of the Study:

  • To review recent progress in understanding "cell-nano" interactions of DNA nanostructures.
  • To focus on tile-based, origami-based, and nanoparticle-templated structures for intracellular applications.
  • To discuss structural parameters and biochemical modifications influencing intracellular delivery.

Main Methods:

  • Review of recent mechanistic studies on DNA nanostructure-cell interactions.
  • Analysis of cellular uptake pathways and involved receptors.
  • Delineation of intracellular trafficking routes and degradation mechanisms.

Main Results:

  • Elucidation of biological mechanisms for cellular uptake of DNA nanostructures.
  • Identification of specific pathways and receptors mediating cellular entry.
  • Understanding of intracellular trafficking and degradation, with strategies for modulation.

Conclusions:

  • Significant progress has been made in understanding DNA nanostructure-cell interactions.
  • Structural parameters and biochemical modifications are key for effective intracellular delivery.
  • Future research should investigate further aspects of "bio-nano" interactions.