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circTADA2As suppress breast cancer progression and metastasis via targeting miR-203a-3p/SOCS3 axis

Jian-Zhen Xu1, Chang-Chun Shao2, Xiao-Jia Wang3

  • 1Department of Bioinformatics, Shantou University Medical College (SUMC), 515041, Shantou, China. jzxu01@stu.edu.cn.

Cell Death & Disease
|February 22, 2019
PubMed

Insights

Circular RNAs (circRNAs) are implicated in cancer. This study found decreased circTADA2A-E6 in breast cancer, acting as a tumor suppressor by regulating miR-203a-3p and SOCS3.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Circular RNAs (circRNAs) play roles in various diseases, particularly cancers.
  • The specific involvement of circRNAs in breast cancer requires further investigation.

Purpose of the Study:

  • To identify differentially expressed circRNAs in breast cancer.
  • To investigate the clinical significance and functional role of circTADA2A in triple-negative breast cancer (TNBC).

Main Methods:

  • circRNA profiling to identify differentially expressed circRNAs.
  • Clinical cohort analysis of circTADA2A expression and patient survival.
  • In vitro and in vivo functional assays for circTADA2A-E6.
  • MiRNA sponge activity evaluation (circTADA2A-E6, miR-203a-3p, SOCS3).

Main Results:

  • Identified 235 differentially expressed circRNAs in breast cancer.
  • Two circRNAs, circTADA2A-E6 and circTADA2A-E5/E6, were significantly decreased in breast cancer patients.
  • Downregulation of circTADA2A correlated with poor survival in TNBC patients.
  • circTADA2A-E6 suppressed tumor cell proliferation, migration, invasion, and clonogenicity.
  • circTADA2A-E6 functions as a miR-203a-3p sponge, restoring SOCS3 expression.

Conclusions:

  • circTADA2As are promising prognostic biomarkers for TNBC.
  • circTADA2A-E6 exhibits tumor-suppressive properties in breast cancer.
  • Targeting the circTADA2As/miRNA/mRNA network offers a potential therapeutic strategy for breast cancer.

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