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Canagliflozin review - safety and efficacy profile in patients with T2DM

Haroon Jakher1, Tara I Chang2, Marilyn Tan3

  • 1Department of Medicine, Stanford University School of Medicine, Palo Alto, CA, USA, hjakher@stanford.edu.

Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy
|February 22, 2019
PubMed

Insights

Canagliflozin, a sodium glucose-cotransporter 2 inhibitor, effectively treats type 2 diabetes. It offers significant cardiovascular and potential renal benefits, though amputation risk needs monitoring.

Area of Science:

  • Pharmacology
  • Cardiology
  • Nephrology

Background:

  • Type 2 diabetes mellitus (T2DM) management requires agents with broad efficacy.
  • Sodium glucose-cotransporter 2 (SGLT2) inhibitors represent a novel therapeutic class.
  • Canagliflozin targets SGLT2 to lower blood glucose.

Purpose of the Study:

  • To review the mechanism of action of SGLT2 inhibitors.
  • To evaluate canagliflozin's efficacy, cardiovascular and renal benefits, and safety.
  • To discuss findings from the CANVAS program and ongoing trials like CREDENCE.

Main Methods:

  • Review of Phase II trials and the large CANVAS program data.
  • Analysis of cardiovascular and renal composite outcomes.
  • Assessment of canagliflozin's safety profile, including adverse events.

Main Results:

  • Canagliflozin improved cardiac and renal biomarkers in Phase II trials.
  • The CANVAS program demonstrated reduced cardiovascular events with canagliflozin.
  • Potential renal benefits and confirmed side effects like genital infections were noted; amputation risk requires further investigation.

Conclusions:

  • Canagliflozin is an effective antidiabetic agent with demonstrated cardiovascular benefits.
  • Evidence suggests likely renal protective effects, warranting further study in specific populations.
  • The safety profile is generally favorable, with specific adverse events identified for clinical awareness.
Keywords:
CANVASInvokana®canagliflozincardiacdiabetesrenalsodium glucose-cotransporter

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