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Ibrutinib-induced cardiomyopathy

Htay Htay Kyi1, Yazan Zayed1, Samer Al Hadidi2

  • 1Internal Medicine Department, Hurley Medical Center/Michigan State University, Flint, USA.

Journal of Community Hospital Internal Medicine Perspectives
|February 22, 2019
PubMed

Insights

Ibrutinib, used for chronic lymphocytic leukemia (CLL), may cause cardiomyopathy, a previously unreported side effect. This case highlights the need for cardiac monitoring in patients receiving this blood cancer medication.

Area of Science:

  • Oncology
  • Cardiology
  • Pharmacology

Background:

  • Ibrutinib is increasingly used for chronic lymphocytic leukemia (CLL) and other hematologic malignancies.
  • Atrial fibrillation is a recognized side effect, but cardiomyopathy has not been previously associated with ibrutinib therapy.

Observation:

  • An 88-year-old male with CLL developed new-onset atrial fibrillation and symptomatic systolic congestive heart failure.
  • These cardiac events occurred one month after initiating ibrutinib treatment.

Findings:

  • Despite discontinuing ibrutinib, the patient exhibited a persistent low ejection fraction four months post-cessation.
  • Cardiac catheterization ruled out ischemic heart disease as the cause of the heart failure.

Implications:

  • This case suggests a potential novel side effect of ibrutinib, specifically cardiomyopathy.
  • Clinicians should consider monitoring cardiac function in patients treated with ibrutinib, particularly for new-onset heart failure symptoms.

Keywords:
CLLIbrutinibLeukemiaheart failureside effects

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