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Updated: Jan 28, 2026
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Laparoscopy-endoscopy Cooperative Surgery for the Treatment of Gastric Gastrointestinal Stromal Tumors
Published on: February 19, 2022
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Gastrointestinal stromal tumors: a comprehensive review
Trisha M Parab1, Michael J DeRogatis1, Alexander M Boaz1
1Department of Surgery, Dignity Health California Hospital Medical Center, Los Angeles, CA, USA.
Journal of Gastrointestinal Oncology
|February 22, 2019
Summary
Gastrointestinal stromal tumors (GISTs) are rare, often asymptomatic cancers. Diagnosis involves CT scans and specific markers, with treatment tailored by risk, including surgery and targeted therapies like imatinib.
Area of Science:
- Gastroenterology
- Oncology
- Pathology
Background:
- Gastrointestinal stromal tumors (GISTs) are rare mesenchymal neoplasms.
- They possess a high potential for malignant transformation.
- Many GISTs are asymptomatic and discovered incidentally.
Purpose of the Study:
- To provide a comprehensive overview of GISTs.
- To discuss epidemiology, clinical presentation, and diagnostic modalities.
- To review current and emerging treatment strategies.
Main Methods:
- Review of existing literature on GISTs.
- Analysis of diagnostic imaging (CT scans) and immunohistochemical markers (CD117, DOG-1).
- Evaluation of risk stratification systems and treatment guidelines.
Main Results:
- GISTs are diagnosed via CT scans and confirmed by markers like CD117.
- Risk stratification is based on tumor size, mitotic rate, location, and perforation.
- Treatment varies from surgical resection for low-risk tumors to targeted therapies (imatinib, sunitinib, ponatinib, regorafenib) for high-risk or metastatic disease.
Conclusions:
- GIST management requires a multidisciplinary approach.
- Risk stratification is crucial for guiding treatment decisions.
- Emerging therapies show promise for refractory or advanced GISTs.
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