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Updated: Jan 28, 2026
08:53
Flow-sorting and Exome Sequencing of the Reed-Sternberg Cells of Classical Hodgkin Lymphoma
Published on: June 10, 2017
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Primary Vaginal Non-Hodgkin Lymphoma
Pamela Contreras-Chavez1, Rolig Aliaga2, Mohammed Samee1
1Internal Medicine, Advocate Illinois Masonic Medical Center, Chicago, USA.
Cureus
|February 22, 2019
Summary
A rare case of vaginal diffuse large B-cell lymphoma (DLBCL), a type of Non-Hodgkin lymphoma (NHL), was successfully treated. This rare vaginal lymphoma achieved complete remission with standard chemotherapy.
Area of Science:
- Oncology
- Hematology
- Gynecologic Oncology
Background:
- Non-Hodgkin lymphoma (NHL) can manifest as extranodal tumors in 25% of cases.
- Primary vaginal lymphoma is exceptionally rare, with limited reported instances.
- This study details a unique case of primary vaginal diffuse large B-cell lymphoma (DLBCL).
Observation:
- A 79-year-old Peruvian woman presented with pelvic pain, vaginal bleeding, and an exophytic vaginal tumor.
- Imaging revealed a large pelvic tumor with bilateral adenomegalies; staging confirmed it as stage one DLBCL.
- Marrow and bone biopsies were negative for metastasis.
Findings:
- The patient received six cycles of CHOP-R chemotherapy (cyclophosphamide, doxorubicin, vincristine, prednisone, and rituximab).
- Complete response and sustained remission were observed during follow-up.
- CHOP-R chemotherapy is effective for primary vaginal DLBCL.
Implications:
- Primary vaginal lymphoma is a rare entity requiring high clinical suspicion.
- Standardized follow-up and relapse management protocols for vaginal lymphoma need further investigation.
- Collaborative studies are essential to enhance understanding and treatment of this rare condition.
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