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Prostate Organoid Cultures as Tools to Translate Genotypes and Mutational Profiles to Pharmacological Responses
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Published on: October 24, 2019

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Senescence controls prostatic neoplasia driven by Pten loss

Maxime Parisotto1,2,3,4, Elise Grelet1,2,3,4, Rana El Bizri1,2,3,4

  • 1Department of Functional Genomics and Cancer, Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France.

Molecular & Cellular Oncology
|February 22, 2019
PubMed
Summary

Pten ablation in mice prostate cells spurs proliferation, causing precancerous lesions. These Pten-deficient cells also show DNA damage and senescence, similar to oncogene-induced senescence.

Keywords:
DNA damagemouse modelprostate cancerreplicative stresssenescence

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