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Stress and Alzheimer's disease
Claus M Escher1, Lena Sannemann2, Frank Jessen2,3
1Department of Psychiatry, University Cologne, Cologne, Germany. claus.escher@uk-koeln.de.
Journal of Neural Transmission (Vienna, Austria : 1996)
|February 22, 2019
Summary
Chronic stress and certain personality traits may increase Alzheimer's disease (AD) risk. This review examines stress, posttraumatic stress disorder, and anxiety's links to AD development and progression.
Area of Science:
- Neuroscience
- Psychiatry
- Gerontology
Background:
- Alzheimer's disease (AD) is the primary cause of dementia globally.
- Increasing life expectancy and demographic shifts predict a rise in AD prevalence.
- The influence of stress on AD development and progression is a growing area of research.
Purpose of the Study:
- To review current literature on the association between personality traits and AD risk.
- To examine dementia risk in individuals with posttraumatic stress disorder (PTSD).
- To explore the role of anxiety symptoms and biological mechanisms in stress-related AD.
Main Methods:
- Literature review of studies on stress, personality, PTSD, anxiety, and Alzheimer's disease.
- Synthesis of findings on the relationship between psychological factors and AD.
- Overview of underlying biological pathways linking stress and AD.
Main Results:
- Evidence suggests chronic stress is a risk factor for AD and can worsen its course.
- Specific personality traits are associated with an increased risk of developing AD.
- Posttraumatic stress disorder and anxiety symptoms are linked to higher dementia risk.
Conclusions:
- Stress, particularly chronic stress, is a significant factor in Alzheimer's disease risk and progression.
- Understanding the interplay between psychological factors and AD is crucial for prevention and treatment strategies.
- Further research into biological mechanisms can illuminate pathways for therapeutic interventions.
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